@article{0438ed549da7400196bdd47b55f36e30,
title = "Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) in normal pressure hydrocephalus misinterpreted as atrophy: autopsy and radiological evidence",
abstract = "Disproportionately enlarged subarachnoid-space hydrocephalus (DESH), a feature of normal pressure hydrocephalus (NPH), is often misinterpreted as cortical atrophy. We report a 67-year-old man with features of NPH but not diagnosed because radiographic findings were interpreted as cortical atrophy. Autopsy showed findings consistent with NPH and no neurodegenerative disease. The second patient with DESH underwent shunt surgery. Entrapped fluid diminished after the surgery, confirming this is not atrophy, but due to a CSF dynamic process. Patients with DESH have tight sulci adjacent to the entrapped fluid pockets, distinguishing it from cortical atrophy. 18F-Fluorodeoxyglucose PET can help differentiate DESH from cortical atrophy.",
keywords = "DESH, FDG PET, Hydrocephalus, MRI, atrophy, ventriculoperitoneal shunting",
author = "McCarty, {Arthur M.} and Jones, {David T.} and Dickson, {Dennis W.} and Graff-Radford, {Neill R.}",
note = "Funding Information: The authors acknowledge support from the brain bank for neurodegenerative disorders at Mayo Clinic, including Rachel LaPaille-Harwood, Virginia Phillips, Michael DeTure, and Monica Castendes-Casey. Funding Information: This work was supported by the NIH under grants [P50-AG016574, P50-NS 072187, and P01-AG003949]; the Rainwater Foundation; the Mangurian Foundation Lewy Body Dementia Program at Mayo Clinic; and the Robert E. Jacoby Professorship. Funding Information: Dennis W. Dickson receives research support from the NIH (P50 AG016574; P50-NS072187; P01-AG003949) from the Rainwater Foundation, the Mangurian Foundation Lewy Body Dementia Program at Mayo Clinic and the Robert E. Jacoby Professorship. Dr. Dickson is an editorial board member of Acta Neuropathologica, Annals of Neurology, Brain, Brain Pathology, and Neuropathology, and he is editor-in-chief of American Journal of Neurodegenerative Disease. Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",
year = "2019",
month = jul,
day = "4",
doi = "10.1080/13554794.2019.1617319",
language = "English (US)",
volume = "25",
pages = "151--155",
journal = "Neurocase",
issn = "1355-4794",
publisher = "Psychology Press Ltd",
number = "3-4",
}