Diffuse smooth muscle proliferation of the lungs with severe pulmonary hypertension

J. Michael Kay, L. M. Kahana, C. Rihal

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We describe the second example of a distinctive clinicopathologic syndrome of severe pulmonary hypertension and interstitial lung disease caused by diffuse smooth muscle proliferation of the lungs (DSMPL) occurring in a 44-year-old man of normal intelligence with no cutaneous or neurological lesions. The smooth muscle proliferation involved the walls of bronchioles, alveoli, small pulmonary arteries, and pulmonary veins. DSMPL is distinct from pulmonary lymphangioleiomyomatosis and tuberous sclerosis, and does not appear to be neoplastic or reactive. The lesions are probably best regarded as multiple hamartomas or 'native benign nodular smooth muscle proliferations'.

Original languageEnglish (US)
Pages (from-to)969-974
Number of pages6
JournalHuman Pathology
Volume27
Issue number9
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Pulmonary Hypertension
Smooth Muscle
Lung
Lymphangioleiomyomatosis
Bronchioles
Tuberous Sclerosis
Hamartoma
Pulmonary Veins
Interstitial Lung Diseases
Intelligence
Pulmonary Artery
Skin

Keywords

  • interstitial lung disease
  • pulmonary hypertension
  • pulmonary lymphangioleiomyomatosis
  • tuberous sclerosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Diffuse smooth muscle proliferation of the lungs with severe pulmonary hypertension. / Kay, J. Michael; Kahana, L. M.; Rihal, C.

In: Human Pathology, Vol. 27, No. 9, 1996, p. 969-974.

Research output: Contribution to journalArticle

Kay, J. Michael ; Kahana, L. M. ; Rihal, C. / Diffuse smooth muscle proliferation of the lungs with severe pulmonary hypertension. In: Human Pathology. 1996 ; Vol. 27, No. 9. pp. 969-974.
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