Diffuse smooth muscle proliferation of the lungs with severe pulmonary hypertension

J. Michael Kay, L. M. Kahana, C. Rihal

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Abstract

We describe the second example of a distinctive clinicopathologic syndrome of severe pulmonary hypertension and interstitial lung disease caused by diffuse smooth muscle proliferation of the lungs (DSMPL) occurring in a 44-year-old man of normal intelligence with no cutaneous or neurological lesions. The smooth muscle proliferation involved the walls of bronchioles, alveoli, small pulmonary arteries, and pulmonary veins. DSMPL is distinct from pulmonary lymphangioleiomyomatosis and tuberous sclerosis, and does not appear to be neoplastic or reactive. The lesions are probably best regarded as multiple hamartomas or 'native benign nodular smooth muscle proliferations'.

Original languageEnglish (US)
Pages (from-to)969-974
Number of pages6
JournalHuman Pathology
Volume27
Issue number9
DOIs
StatePublished - Jan 1 1996

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Keywords

  • interstitial lung disease
  • pulmonary hypertension
  • pulmonary lymphangioleiomyomatosis
  • tuberous sclerosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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