TY - JOUR
T1 - Diffuse dermal angiomatosis of the breast
T2 - Clinicopathologic study of 5 patients
AU - Tollefson, Megha M.
AU - McEvoy, Marian T.
AU - Torgerson, Rochelle R.
AU - Bridges, Alina G.
N1 - Publisher Copyright:
© 2014 American Academy of Dermatology, Inc.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Background Diffuse dermal angiomatosis (DDA) is a rare skin condition considered to be a type of reactive angioendotheliomatosis. Histologic features are quite characteristic. It has been reported in association with vaso-occlusive disease, trauma, or underlying hypercoagulability. In the past, it was thought to be most common on the lower extremities. Objective The purpose of this study was to describe the clinical and histologic features of 5 patients with DDA. Methods The clinical and histologic features of 5 patients with DDA were evaluated. Results Five women (47-58 years old) had DDA of the breast. Histologic examination showed a diffuse proliferation of benign endothelial cells between the collagen bundles throughout the dermis. Limitations The main limitation of our study is the limited number of patients. Conclusion Involvement of the breast is much more common than previously reported. Smoking seems to be a strong risk factor for the disease. Revascularization, oral corticosteroids, and oral anticoagulation have all been reported to be somewhat successful in the treatment of DDA of the breast.
AB - Background Diffuse dermal angiomatosis (DDA) is a rare skin condition considered to be a type of reactive angioendotheliomatosis. Histologic features are quite characteristic. It has been reported in association with vaso-occlusive disease, trauma, or underlying hypercoagulability. In the past, it was thought to be most common on the lower extremities. Objective The purpose of this study was to describe the clinical and histologic features of 5 patients with DDA. Methods The clinical and histologic features of 5 patients with DDA were evaluated. Results Five women (47-58 years old) had DDA of the breast. Histologic examination showed a diffuse proliferation of benign endothelial cells between the collagen bundles throughout the dermis. Limitations The main limitation of our study is the limited number of patients. Conclusion Involvement of the breast is much more common than previously reported. Smoking seems to be a strong risk factor for the disease. Revascularization, oral corticosteroids, and oral anticoagulation have all been reported to be somewhat successful in the treatment of DDA of the breast.
KW - breast
KW - breast reduction mammaplasty
KW - dermal angiomatosis
KW - reactive angioendotheliomatosis
KW - vascular proliferation
KW - vaso-occlusive disease
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U2 - 10.1016/j.jaad.2014.08.015
DO - 10.1016/j.jaad.2014.08.015
M3 - Article
C2 - 25264238
AN - SCOPUS:84925226412
SN - 0190-9622
VL - 71
SP - 1212
EP - 1217
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -