Abstract
Sphere-forming cochlear stem cells/progenitors have recently been isolated from the postnatal mouse organ of Corti. However, self-renewal of the cochlear progenitors remains to be elucidated. Here we demonstrate the renewable cochlear neural progenitors from the postnatal Immortomouse organ of Corti containing a temperature-sensitive SV40 that have the potential to differentiate into hair cell-, neuron-, and supporting cell-like phenotypes under the guidance of sonic hedgehog, epidermal growth factor, retinoic acid, and brain-derived neurotrophic factor, herein termed SERB. This work provides a rationale for using cochlear neural progenitors in possible cell replacement of lost hair cells and neurons in degenerative hearing disorders.
Original language | English (US) |
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Pages (from-to) | 11-22 |
Number of pages | 12 |
Journal | Molecular and Cellular Pharmacology |
Volume | 1 |
Issue number | 1 |
DOIs | |
State | Published - 2009 |
Keywords
- Cochlear neural progenitor
- Differentiation
- Growth factor
- Mouse
- SV40
ASJC Scopus subject areas
- Molecular Biology
- Pharmaceutical Science