Differential expression of DUSP6 with expression of ERK and Ki-67 in non-small cell lung carcinoma

Hyunjung Lee, Jin Man Kim, Song Mei Huang, Seung Kiel Park, Dong Hoon Kim, Do Hyung Kim, Choong Sik Lee, Kwang Sun Suh, Eunhee S. Yi, Kyung Hee Kim

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Dual specificity phosphatase 6 (DUSP6) is a member of the MAP kinase phophatase family. DUSP6 inactivates extracellular signal-regulated kinase (ERK), belonging to the MAP kinase family, and can act in tumor suppressive pathways. The aim of this study was to investigate associations of DUSP6 expression with expression of ERK and Ki-67 and with clinicopathological parameters in lung adenocarcinoma and squamous cell carcinoma. A total of 102 squamous cell carcinomas and 66 adenocarcinomas were studied using immunohistochemistry for DUSP6, ERK1/2, and Ki-67. In 66 adenocarcinomas, high DUSP6 expression was positively correlated with ERK1/2 expression. High DUSP6 expression was correlated with lower histological grade and lower Ki-67 index in the adenocarcinomas. In 102 squamous cell carcinomas, high DUSP6 expression was correlated with lower ERK expression, with greater smoking pack-years, but not with the Ki-67 index. These results indicate that DUSP6 acts as a negative feedback regulator of ERK in adenocarcinoma progression, but that DUSP6 does not play a role in the downregulation of ERK in squamous cell carcinoma. The differential expression of DUSP6 correlated with Ki-67 index, suggesting that DUSP6 plays an important role in cancer resistance in different subtypes of non-small cell lung carcinoma.

Original languageEnglish (US)
Pages (from-to)428-432
Number of pages5
JournalPathology Research and Practice
Volume207
Issue number7
DOIs
StatePublished - Jul 15 2011

Keywords

  • Adenocarcinoma
  • Dual specificity phosphatase 6
  • Extracellular signal-regulated kinase
  • Lung
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

Fingerprint Dive into the research topics of 'Differential expression of DUSP6 with expression of ERK and Ki-67 in non-small cell lung carcinoma'. Together they form a unique fingerprint.

Cite this