Differential effects of low calcium on signal transmission from rods and cones to horizontal cells in carp ritina

Hai Long Wang, Xiong Li Yang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Intracellular recordings were made from neurons in the superfused isolated carp retina and the effects of calcium on synaptic transmission from cones and rods to horizontal cells were studied by changing the ionic composition of the external medium. When extracellular Ca2+ is lowered from 1.2 mmol/L to 0.1 mmol/L, both cone- and rod-horizontal cells (Cone-HC and Rod-HC) are depolarized, but light responsiveness of these cells are differentially affected; light responses of Cone-HCs are reduced in size, whereas those of Rod-HCs are significantly enhanced. In 0.1 mmol/L Ca2+, glutamate-isolated P III components, both photopic and scotopic, are enhanced, suggesting that the differential effects of low calcium on the horizontal cells must occur during signal transferring from photoreceptors to horizontal cells. Similar to the effect of 0.1 mmol/L Ca2+, phosphodiesterase inhibitor IBMX (50 μmol/L) is also capable of enhancing light responsiveness of both L-type Cone-HC and Rod-HC. These results suggest that the differentail effects of low calcium on the two types of horizontal cells may be due to different changes in the calcium influx into the receptor terminals.

Original languageEnglish (US)
Pages (from-to)112-124
Number of pages13
JournalActa Physiologica Sinica
Volume48
Issue number2
StatePublished - 1996
Externally publishedYes

Fingerprint

Vertebrate Photoreceptor Cells
Carps
Calcium
Light
1-Methyl-3-isobutylxanthine
Phosphodiesterase Inhibitors
Synaptic Transmission
Retina
Glutamic Acid
Neurons

Keywords

  • Calcium
  • Photoreceptor
  • Retinal horizontal cell
  • Synaptic transmission

ASJC Scopus subject areas

  • Physiology

Cite this

Differential effects of low calcium on signal transmission from rods and cones to horizontal cells in carp ritina. / Wang, Hai Long; Yang, Xiong Li.

In: Acta Physiologica Sinica, Vol. 48, No. 2, 1996, p. 112-124.

Research output: Contribution to journalArticle

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