Dietary, supplement, and adipose tissue tocopherol levels in relation to prostate cancer aggressiveness among African and European Americans: The North Carolina-Louisiana Prostate Cancer Project (PCaP)

Samuel Antwi, Susan E. Steck, L. Joseph Su, James R. Hébert, Hongmei Zhang, Elizabeth T H Fontham, Gary J. Smith, Jeannette T. Bensen, James L. Mohler, Lenore Arab

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background Controversies remain over the safety and efficacy of vitamin E (i.e., α-tocopherol) supplementation use for the prevention of prostate cancer (CaP); however, associations of different tocopherol forms and CaP aggressiveness have yet to be examined. Methods This study examined whether food intake of tocopherols, vitamin E supplement use, and adipose tissue biomarkers of tocopherol were associated with CaP aggressiveness among African-American (AA, n-=-1,023) and European-American (EA, n-=-1,079) men diagnosed with incident CaP. Dietary tocopherols were estimated from a food frequency questionnaire, supplement use from questionnaire/inventory, and biomarkers from abdominal adipose samples measured using high-performance liquid chromatography. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were estimated from logistic regression comparing high-aggressive CaP to low/intermediate aggressive CaP, adjusting for covariates. Results Dietary intakes of α-and δ-tocopherol were related inversely to CaP aggressiveness among EAs [OR (95%CI), highest versus lowest quartile: α-tocopherol, 0.34 (0.17-0.69), Ptrend-=-0.006; δ-tocopherol, 0.45 (0.21-0.95) Ptrend-=-0.007]. Inverse associations between dietary and supplemental α-tocopherol and CaP aggressiveness were observed among AAs, though these did not reach statistical significance [OR (95%CI), highest versus lowest quartile: dietary α-tocopherol, 0.58 (0.28-1.19), Ptrend-=-0.20; supplemental α-tocopherol, 0.64 (0.31-1.21) Ptrend-=-0.15]. No significant association was observed between adipose tocopherol levels and CaP aggressiveness [OR (95%CI), highest versus lowest quartiles of α-tocopherol for EAs 1.43 (0.66-3.11) and AAs 0.66 (0.27-1.62)]. Conclusions The inverse associations observed between dietary sources of tocopherols and CaP aggressiveness suggests a beneficial role of food sources of these tocopherols in CaP aggressiveness.

Original languageEnglish (US)
Pages (from-to)1419-1435
Number of pages17
JournalProstate
Volume75
Issue number13
DOIs
StatePublished - Sep 1 2015

Keywords

  • adipose tissue
  • diet
  • nutritional biomarkers
  • prostate cancer
  • supplement
  • tocopherols
  • vitamin E

ASJC Scopus subject areas

  • Urology
  • Oncology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Dietary, supplement, and adipose tissue tocopherol levels in relation to prostate cancer aggressiveness among African and European Americans: The North Carolina-Louisiana Prostate Cancer Project (PCaP)'. Together they form a unique fingerprint.

  • Cite this