Dietary, supplement, and adipose tissue tocopherol levels in relation to prostate cancer aggressiveness among African and European Americans: The North Carolina-Louisiana Prostate Cancer Project (PCaP)

Samuel O. Antwi, Susan E. Steck, L. Joseph Su, James R. Hébert, Hongmei Zhang, Elizabeth T.H. Fontham, Gary J. Smith, Jeannette T. Bensen, James L. Mohler, Lenore Arab

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background Controversies remain over the safety and efficacy of vitamin E (i.e., α-tocopherol) supplementation use for the prevention of prostate cancer (CaP); however, associations of different tocopherol forms and CaP aggressiveness have yet to be examined. Methods This study examined whether food intake of tocopherols, vitamin E supplement use, and adipose tissue biomarkers of tocopherol were associated with CaP aggressiveness among African-American (AA, n-=-1,023) and European-American (EA, n-=-1,079) men diagnosed with incident CaP. Dietary tocopherols were estimated from a food frequency questionnaire, supplement use from questionnaire/inventory, and biomarkers from abdominal adipose samples measured using high-performance liquid chromatography. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were estimated from logistic regression comparing high-aggressive CaP to low/intermediate aggressive CaP, adjusting for covariates. Results Dietary intakes of α-and δ-tocopherol were related inversely to CaP aggressiveness among EAs [OR (95%CI), highest versus lowest quartile: α-tocopherol, 0.34 (0.17-0.69), Ptrend-=-0.006; δ-tocopherol, 0.45 (0.21-0.95) Ptrend-=-0.007]. Inverse associations between dietary and supplemental α-tocopherol and CaP aggressiveness were observed among AAs, though these did not reach statistical significance [OR (95%CI), highest versus lowest quartile: dietary α-tocopherol, 0.58 (0.28-1.19), Ptrend-=-0.20; supplemental α-tocopherol, 0.64 (0.31-1.21) Ptrend-=-0.15]. No significant association was observed between adipose tocopherol levels and CaP aggressiveness [OR (95%CI), highest versus lowest quartiles of α-tocopherol for EAs 1.43 (0.66-3.11) and AAs 0.66 (0.27-1.62)]. Conclusions The inverse associations observed between dietary sources of tocopherols and CaP aggressiveness suggests a beneficial role of food sources of these tocopherols in CaP aggressiveness.

Original languageEnglish (US)
Pages (from-to)1419-1435
Number of pages17
JournalProstate
Volume75
Issue number13
DOIs
StatePublished - Sep 1 2015

Keywords

  • adipose tissue
  • diet
  • nutritional biomarkers
  • prostate cancer
  • supplement
  • tocopherols
  • vitamin E

ASJC Scopus subject areas

  • Oncology
  • Urology

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