Dietary, supplement, and adipose tissue tocopherol levels in relation to prostate cancer aggressiveness among African and European Americans: The North Carolina-Louisiana Prostate Cancer Project (PCaP)

Samuel Antwi, Susan E. Steck, L. Joseph Su, James R. Hébert, Hongmei Zhang, Elizabeth T H Fontham, Gary J. Smith, Jeannette T. Bensen, James L. Mohler, Lenore Arab

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Controversies remain over the safety and efficacy of vitamin E (i.e., α-tocopherol) supplementation use for the prevention of prostate cancer (CaP); however, associations of different tocopherol forms and CaP aggressiveness have yet to be examined. Methods This study examined whether food intake of tocopherols, vitamin E supplement use, and adipose tissue biomarkers of tocopherol were associated with CaP aggressiveness among African-American (AA, n-=-1,023) and European-American (EA, n-=-1,079) men diagnosed with incident CaP. Dietary tocopherols were estimated from a food frequency questionnaire, supplement use from questionnaire/inventory, and biomarkers from abdominal adipose samples measured using high-performance liquid chromatography. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were estimated from logistic regression comparing high-aggressive CaP to low/intermediate aggressive CaP, adjusting for covariates. Results Dietary intakes of α-and δ-tocopherol were related inversely to CaP aggressiveness among EAs [OR (95%CI), highest versus lowest quartile: α-tocopherol, 0.34 (0.17-0.69), Ptrend-=-0.006; δ-tocopherol, 0.45 (0.21-0.95) Ptrend-=-0.007]. Inverse associations between dietary and supplemental α-tocopherol and CaP aggressiveness were observed among AAs, though these did not reach statistical significance [OR (95%CI), highest versus lowest quartile: dietary α-tocopherol, 0.58 (0.28-1.19), Ptrend-=-0.20; supplemental α-tocopherol, 0.64 (0.31-1.21) Ptrend-=-0.15]. No significant association was observed between adipose tocopherol levels and CaP aggressiveness [OR (95%CI), highest versus lowest quartiles of α-tocopherol for EAs 1.43 (0.66-3.11) and AAs 0.66 (0.27-1.62)]. Conclusions The inverse associations observed between dietary sources of tocopherols and CaP aggressiveness suggests a beneficial role of food sources of these tocopherols in CaP aggressiveness.

Original languageEnglish (US)
Pages (from-to)1419-1435
Number of pages17
JournalProstate
Volume75
Issue number13
DOIs
StatePublished - Sep 1 2015

Fingerprint

Tocopherols
Dietary Supplements
African Americans
Adipose Tissue
Prostatic Neoplasms
Odds Ratio
Confidence Intervals
Prostate Cancer, Hereditary, 7
Vitamin E
Biomarkers
Food

Keywords

  • adipose tissue
  • diet
  • nutritional biomarkers
  • prostate cancer
  • supplement
  • tocopherols
  • vitamin E

ASJC Scopus subject areas

  • Urology
  • Oncology
  • Medicine(all)

Cite this

Dietary, supplement, and adipose tissue tocopherol levels in relation to prostate cancer aggressiveness among African and European Americans : The North Carolina-Louisiana Prostate Cancer Project (PCaP). / Antwi, Samuel; Steck, Susan E.; Su, L. Joseph; Hébert, James R.; Zhang, Hongmei; Fontham, Elizabeth T H; Smith, Gary J.; Bensen, Jeannette T.; Mohler, James L.; Arab, Lenore.

In: Prostate, Vol. 75, No. 13, 01.09.2015, p. 1419-1435.

Research output: Contribution to journalArticle

Antwi, Samuel ; Steck, Susan E. ; Su, L. Joseph ; Hébert, James R. ; Zhang, Hongmei ; Fontham, Elizabeth T H ; Smith, Gary J. ; Bensen, Jeannette T. ; Mohler, James L. ; Arab, Lenore. / Dietary, supplement, and adipose tissue tocopherol levels in relation to prostate cancer aggressiveness among African and European Americans : The North Carolina-Louisiana Prostate Cancer Project (PCaP). In: Prostate. 2015 ; Vol. 75, No. 13. pp. 1419-1435.
@article{37d33649022b4211a137ca5878a18fee,
title = "Dietary, supplement, and adipose tissue tocopherol levels in relation to prostate cancer aggressiveness among African and European Americans: The North Carolina-Louisiana Prostate Cancer Project (PCaP)",
abstract = "Background Controversies remain over the safety and efficacy of vitamin E (i.e., α-tocopherol) supplementation use for the prevention of prostate cancer (CaP); however, associations of different tocopherol forms and CaP aggressiveness have yet to be examined. Methods This study examined whether food intake of tocopherols, vitamin E supplement use, and adipose tissue biomarkers of tocopherol were associated with CaP aggressiveness among African-American (AA, n-=-1,023) and European-American (EA, n-=-1,079) men diagnosed with incident CaP. Dietary tocopherols were estimated from a food frequency questionnaire, supplement use from questionnaire/inventory, and biomarkers from abdominal adipose samples measured using high-performance liquid chromatography. Odds ratios (ORs) and 95{\%} confidence intervals (95{\%}CIs) were estimated from logistic regression comparing high-aggressive CaP to low/intermediate aggressive CaP, adjusting for covariates. Results Dietary intakes of α-and δ-tocopherol were related inversely to CaP aggressiveness among EAs [OR (95{\%}CI), highest versus lowest quartile: α-tocopherol, 0.34 (0.17-0.69), Ptrend-=-0.006; δ-tocopherol, 0.45 (0.21-0.95) Ptrend-=-0.007]. Inverse associations between dietary and supplemental α-tocopherol and CaP aggressiveness were observed among AAs, though these did not reach statistical significance [OR (95{\%}CI), highest versus lowest quartile: dietary α-tocopherol, 0.58 (0.28-1.19), Ptrend-=-0.20; supplemental α-tocopherol, 0.64 (0.31-1.21) Ptrend-=-0.15]. No significant association was observed between adipose tocopherol levels and CaP aggressiveness [OR (95{\%}CI), highest versus lowest quartiles of α-tocopherol for EAs 1.43 (0.66-3.11) and AAs 0.66 (0.27-1.62)]. Conclusions The inverse associations observed between dietary sources of tocopherols and CaP aggressiveness suggests a beneficial role of food sources of these tocopherols in CaP aggressiveness.",
keywords = "adipose tissue, diet, nutritional biomarkers, prostate cancer, supplement, tocopherols, vitamin E",
author = "Samuel Antwi and Steck, {Susan E.} and Su, {L. Joseph} and H{\'e}bert, {James R.} and Hongmei Zhang and Fontham, {Elizabeth T H} and Smith, {Gary J.} and Bensen, {Jeannette T.} and Mohler, {James L.} and Lenore Arab",
year = "2015",
month = "9",
day = "1",
doi = "10.1002/pros.23025",
language = "English (US)",
volume = "75",
pages = "1419--1435",
journal = "Prostate",
issn = "0270-4137",
publisher = "Wiley-Liss Inc.",
number = "13",

}

TY - JOUR

T1 - Dietary, supplement, and adipose tissue tocopherol levels in relation to prostate cancer aggressiveness among African and European Americans

T2 - The North Carolina-Louisiana Prostate Cancer Project (PCaP)

AU - Antwi, Samuel

AU - Steck, Susan E.

AU - Su, L. Joseph

AU - Hébert, James R.

AU - Zhang, Hongmei

AU - Fontham, Elizabeth T H

AU - Smith, Gary J.

AU - Bensen, Jeannette T.

AU - Mohler, James L.

AU - Arab, Lenore

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Background Controversies remain over the safety and efficacy of vitamin E (i.e., α-tocopherol) supplementation use for the prevention of prostate cancer (CaP); however, associations of different tocopherol forms and CaP aggressiveness have yet to be examined. Methods This study examined whether food intake of tocopherols, vitamin E supplement use, and adipose tissue biomarkers of tocopherol were associated with CaP aggressiveness among African-American (AA, n-=-1,023) and European-American (EA, n-=-1,079) men diagnosed with incident CaP. Dietary tocopherols were estimated from a food frequency questionnaire, supplement use from questionnaire/inventory, and biomarkers from abdominal adipose samples measured using high-performance liquid chromatography. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were estimated from logistic regression comparing high-aggressive CaP to low/intermediate aggressive CaP, adjusting for covariates. Results Dietary intakes of α-and δ-tocopherol were related inversely to CaP aggressiveness among EAs [OR (95%CI), highest versus lowest quartile: α-tocopherol, 0.34 (0.17-0.69), Ptrend-=-0.006; δ-tocopherol, 0.45 (0.21-0.95) Ptrend-=-0.007]. Inverse associations between dietary and supplemental α-tocopherol and CaP aggressiveness were observed among AAs, though these did not reach statistical significance [OR (95%CI), highest versus lowest quartile: dietary α-tocopherol, 0.58 (0.28-1.19), Ptrend-=-0.20; supplemental α-tocopherol, 0.64 (0.31-1.21) Ptrend-=-0.15]. No significant association was observed between adipose tocopherol levels and CaP aggressiveness [OR (95%CI), highest versus lowest quartiles of α-tocopherol for EAs 1.43 (0.66-3.11) and AAs 0.66 (0.27-1.62)]. Conclusions The inverse associations observed between dietary sources of tocopherols and CaP aggressiveness suggests a beneficial role of food sources of these tocopherols in CaP aggressiveness.

AB - Background Controversies remain over the safety and efficacy of vitamin E (i.e., α-tocopherol) supplementation use for the prevention of prostate cancer (CaP); however, associations of different tocopherol forms and CaP aggressiveness have yet to be examined. Methods This study examined whether food intake of tocopherols, vitamin E supplement use, and adipose tissue biomarkers of tocopherol were associated with CaP aggressiveness among African-American (AA, n-=-1,023) and European-American (EA, n-=-1,079) men diagnosed with incident CaP. Dietary tocopherols were estimated from a food frequency questionnaire, supplement use from questionnaire/inventory, and biomarkers from abdominal adipose samples measured using high-performance liquid chromatography. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were estimated from logistic regression comparing high-aggressive CaP to low/intermediate aggressive CaP, adjusting for covariates. Results Dietary intakes of α-and δ-tocopherol were related inversely to CaP aggressiveness among EAs [OR (95%CI), highest versus lowest quartile: α-tocopherol, 0.34 (0.17-0.69), Ptrend-=-0.006; δ-tocopherol, 0.45 (0.21-0.95) Ptrend-=-0.007]. Inverse associations between dietary and supplemental α-tocopherol and CaP aggressiveness were observed among AAs, though these did not reach statistical significance [OR (95%CI), highest versus lowest quartile: dietary α-tocopherol, 0.58 (0.28-1.19), Ptrend-=-0.20; supplemental α-tocopherol, 0.64 (0.31-1.21) Ptrend-=-0.15]. No significant association was observed between adipose tocopherol levels and CaP aggressiveness [OR (95%CI), highest versus lowest quartiles of α-tocopherol for EAs 1.43 (0.66-3.11) and AAs 0.66 (0.27-1.62)]. Conclusions The inverse associations observed between dietary sources of tocopherols and CaP aggressiveness suggests a beneficial role of food sources of these tocopherols in CaP aggressiveness.

KW - adipose tissue

KW - diet

KW - nutritional biomarkers

KW - prostate cancer

KW - supplement

KW - tocopherols

KW - vitamin E

UR - http://www.scopus.com/inward/record.url?scp=84939255711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939255711&partnerID=8YFLogxK

U2 - 10.1002/pros.23025

DO - 10.1002/pros.23025

M3 - Article

C2 - 26053590

AN - SCOPUS:84939255711

VL - 75

SP - 1419

EP - 1435

JO - Prostate

JF - Prostate

SN - 0270-4137

IS - 13

ER -