Dietary patterns and breast density in the Minnesota Breast Cancer Family Study

Marilyn Tseng, Robert A. Vierkant, Lawrence H. Kushi, Thomas A. Sellers, Celine M Vachon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Whether dietary patterns, rather than single foods or nutrients, are associated with breast density is not known. We investigated this in the Minnesota Breast Cancer Family Study. Methods: Participants completed a 153-item food frequency questionnaire and provided screening mammograms for breast density assessment using a computer-assisted method. We used multivariate linear regression to quantify dietary pattern-breast density associations. Results: Among 3,147 women with dietary information, three dietary patterns emerged from principal components analysis: a fruit-vegetable-cereal pattern, a salad-sauce-pasta/grain pattern, and a meat-starch pattern. Among 1,286 women with breast density estimates, the fruit-vegetable-cereal and salad-sauce-pasta/grain patterns were inversely associated with percent breast density only in stratified analyses. The fruit-vegetable-cereal pattern was inversely associated with breast density among premenopausal women (β = -0.13, p = 0.09; interaction p = 0.009) and current smokers, (β = -0.30, p = 0.02; interaction p = 0.05), while the salad-sauce-pasta/grain was inversely associated with breast density among current smokers (β = -0.27, p = 0.06; interaction p = 0.006). Conclusion: Overall our results do not provide strong evidence for associations of dietary patterns with breast density. Suggestive inverse associations for the fruit-vegetable-cereal and salad-sauce-pasta/grain dietary patterns among smokers are consistent with previous reports and leave open the possibility that some dietary patterns influence breast density in population subsets. Nevertheless, these findings require confirmation, and their underlying reasons have yet to be clarified.

Original languageEnglish (US)
Pages (from-to)481-489
Number of pages9
JournalCancer Causes and Control
Volume19
Issue number5
DOIs
StatePublished - Jun 2008

Fingerprint

Breast Neoplasms
Vegetables
Fruit
Food
Breast Density
Principal Component Analysis
Starch
Meat
Linear Models
Edible Grain
Population

Keywords

  • Breast neoplasms
  • Diet
  • Dietary patterns
  • Mammographic density

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Dietary patterns and breast density in the Minnesota Breast Cancer Family Study. / Tseng, Marilyn; Vierkant, Robert A.; Kushi, Lawrence H.; Sellers, Thomas A.; Vachon, Celine M.

In: Cancer Causes and Control, Vol. 19, No. 5, 06.2008, p. 481-489.

Research output: Contribution to journalArticle

Tseng, Marilyn ; Vierkant, Robert A. ; Kushi, Lawrence H. ; Sellers, Thomas A. ; Vachon, Celine M. / Dietary patterns and breast density in the Minnesota Breast Cancer Family Study. In: Cancer Causes and Control. 2008 ; Vol. 19, No. 5. pp. 481-489.
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