TY - JOUR
T1 - Dietary patterns and breast density in the Minnesota Breast Cancer Family Study
AU - Tseng, Marilyn
AU - Vierkant, Robert A.
AU - Kushi, Lawrence H.
AU - Sellers, Thomas A.
AU - Vachon, Celine M.
N1 - Funding Information:
Acknowledgments The authors thank Ms. Xiaoxing He for her assistance in data analysis, and Ms. Fang-Fang Wu for her work in reading mammograms. Grant support: Supported by grant 5 R03 CA097779-02 from the National Institutes of Health.
PY - 2008/6
Y1 - 2008/6
N2 - Objective: Whether dietary patterns, rather than single foods or nutrients, are associated with breast density is not known. We investigated this in the Minnesota Breast Cancer Family Study. Methods: Participants completed a 153-item food frequency questionnaire and provided screening mammograms for breast density assessment using a computer-assisted method. We used multivariate linear regression to quantify dietary pattern-breast density associations. Results: Among 3,147 women with dietary information, three dietary patterns emerged from principal components analysis: a fruit-vegetable-cereal pattern, a salad-sauce-pasta/grain pattern, and a meat-starch pattern. Among 1,286 women with breast density estimates, the fruit-vegetable-cereal and salad-sauce-pasta/grain patterns were inversely associated with percent breast density only in stratified analyses. The fruit-vegetable-cereal pattern was inversely associated with breast density among premenopausal women (β = -0.13, p = 0.09; interaction p = 0.009) and current smokers, (β = -0.30, p = 0.02; interaction p = 0.05), while the salad-sauce-pasta/grain was inversely associated with breast density among current smokers (β = -0.27, p = 0.06; interaction p = 0.006). Conclusion: Overall our results do not provide strong evidence for associations of dietary patterns with breast density. Suggestive inverse associations for the fruit-vegetable-cereal and salad-sauce-pasta/grain dietary patterns among smokers are consistent with previous reports and leave open the possibility that some dietary patterns influence breast density in population subsets. Nevertheless, these findings require confirmation, and their underlying reasons have yet to be clarified.
AB - Objective: Whether dietary patterns, rather than single foods or nutrients, are associated with breast density is not known. We investigated this in the Minnesota Breast Cancer Family Study. Methods: Participants completed a 153-item food frequency questionnaire and provided screening mammograms for breast density assessment using a computer-assisted method. We used multivariate linear regression to quantify dietary pattern-breast density associations. Results: Among 3,147 women with dietary information, three dietary patterns emerged from principal components analysis: a fruit-vegetable-cereal pattern, a salad-sauce-pasta/grain pattern, and a meat-starch pattern. Among 1,286 women with breast density estimates, the fruit-vegetable-cereal and salad-sauce-pasta/grain patterns were inversely associated with percent breast density only in stratified analyses. The fruit-vegetable-cereal pattern was inversely associated with breast density among premenopausal women (β = -0.13, p = 0.09; interaction p = 0.009) and current smokers, (β = -0.30, p = 0.02; interaction p = 0.05), while the salad-sauce-pasta/grain was inversely associated with breast density among current smokers (β = -0.27, p = 0.06; interaction p = 0.006). Conclusion: Overall our results do not provide strong evidence for associations of dietary patterns with breast density. Suggestive inverse associations for the fruit-vegetable-cereal and salad-sauce-pasta/grain dietary patterns among smokers are consistent with previous reports and leave open the possibility that some dietary patterns influence breast density in population subsets. Nevertheless, these findings require confirmation, and their underlying reasons have yet to be clarified.
KW - Breast neoplasms
KW - Diet
KW - Dietary patterns
KW - Mammographic density
UR - http://www.scopus.com/inward/record.url?scp=43749088891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43749088891&partnerID=8YFLogxK
U2 - 10.1007/s10552-008-9109-x
DO - 10.1007/s10552-008-9109-x
M3 - Article
C2 - 18202830
AN - SCOPUS:43749088891
SN - 0957-5243
VL - 19
SP - 481
EP - 489
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 5
ER -