Diazepam and human memory: Influence on acquisition, retrieval, and state-dependent learning

1. 1. Diazepam's capacity to influence learning and memory processes in man was evaluated using five tasks involving free and cued recall and mental imagery. 2. 2. State-dependent learning was assessed by manipulating the drug condition (diazepam or placebo) during the learning and recall sessions. 3. 3. Results indicated that 0.3 mg/kg diazepam administered orally significantly impaired subjects' ability to learn new material using a variety of procedures. 4. 4. Retrieval of material once learned was not severely impaired by the drug. 5. 5. Some evidence for state dependency was found, but additional studies are required.