Diazepam and human memory: Influence on acquisition, retrieval, and state-dependent learning

Ronald C. Petersen, Mohamed M. Ghoneim

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

1. 1. Diazepam's capacity to influence learning and memory processes in man was evaluated using five tasks involving free and cued recall and mental imagery. 2. 2. State-dependent learning was assessed by manipulating the drug condition (diazepam or placebo) during the learning and recall sessions. 3. 3. Results indicated that 0.3 mg/kg diazepam administered orally significantly impaired subjects' ability to learn new material using a variety of procedures. 4. 4. Retrieval of material once learned was not severely impaired by the drug. 5. 5. Some evidence for state dependency was found, but additional studies are required.

Original languageEnglish (US)
Pages (from-to)81-89
Number of pages9
JournalProgress in Neuro-Psychopharmacology
Volume4
Issue number1
DOIs
StatePublished - 1980

Keywords

  • benzodiazepines
  • diazepam
  • learning
  • memory
  • state-dependent learning

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health
  • Pharmacology (medical)

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