Diagnostic consideration of spindle cell proliferations in the breast: A case-based perspective

Sejal M Shah, Katrina Nesta Glazebrook, Carol Reynolds

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 52-year-old woman with noninsulin dependent diabetes mellitus was found to have a 3.5-cm irregular spiculated right breast mass by mammography worrisome for malignancy. The patient underwent core needle biopsy followed by mastectomy and sentinel node biopsy. The pathologic examination of the breast mass revealed "fibromatosis-like" spindle cell carcinoma. The sentinel lymph node was negative for metastatic disease. This case illustrates the spindle cell variant of metaplastic carcinoma, which can be diagnostically challenging, especially in limited core biopsy material. Recent studies have highlighted the use of various immunohistochemical stains in the evaluation of spindle cell proliferations in the breast. We propose the use of several different keratin stains and the inclusion of p63 as part of the diagnostic workup of challenging spindle cell lesions of the breast.

Original languageEnglish (US)
Pages (from-to)172-176
Number of pages5
JournalPathology Case Reviews
Volume14
Issue number4
DOIs
StatePublished - Jul 2009

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Breast
Cell Proliferation
Coloring Agents
Carcinoma
Large-Core Needle Biopsy
Biopsy
Fibroma
Mastectomy
Mammography
Keratins
Type 2 Diabetes Mellitus
Neoplasms

Keywords

  • "Fibromatosislike" spindle cell carcinoma
  • Fibromatosis
  • Immunohistochemistry
  • Metaplastic carcinoma
  • Spindle cell tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Diagnostic consideration of spindle cell proliferations in the breast : A case-based perspective. / Shah, Sejal M; Glazebrook, Katrina Nesta; Reynolds, Carol.

In: Pathology Case Reviews, Vol. 14, No. 4, 07.2009, p. 172-176.

Research output: Contribution to journalArticle

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