Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

Morie A. Gertz; Merrill D. Benson; Peter J. Dyck; Martha Grogan; Terresa Coelho; Marcia Cruz; John L. Berk; Violaine Plante-Bordeneuve; Hartmut H.J. Schmidt; Giampaolo Merlini

doi:10.1016/j.jacc.2015.09.075

Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

Morie A. Gertz, Merrill D. Benson, Peter J. Dyck, Martha Grogan, Terresa Coelho, Marcia Cruz, John L. Berk, Violaine Plante-Bordeneuve, Hartmut H.J. Schmidt, Giampaolo Merlini

Research output: Contribution to journal › Review article › peer-review

197 Scopus citations

Abstract

Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.

Original language	English (US)
Pages (from-to)	2451-2466
Number of pages	16
Journal	Journal of the American College of Cardiology
Volume	66
Issue number	21
DOIs	https://doi.org/10.1016/j.jacc.2015.09.075
State	Published - 2015

Keywords

familial amyloid cardiomyopathy
familial amyloid polyneuropathy
genetics
liver transplantation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacc.2015.09.075

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title = "Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis",

abstract = "Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.",

keywords = "familial amyloid cardiomyopathy, familial amyloid polyneuropathy, genetics, liver transplantation",

author = "Gertz, {Morie A.} and Benson, {Merrill D.} and Dyck, {Peter J.} and Martha Grogan and Terresa Coelho and Marcia Cruz and Berk, {John L.} and Violaine Plante-Bordeneuve and Schmidt, {Hartmut H.J.} and Giampaolo Merlini",

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T1 - Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

AU - Gertz, Morie A.

AU - Benson, Merrill D.

AU - Dyck, Peter J.

AU - Grogan, Martha

AU - Coelho, Terresa

AU - Cruz, Marcia

AU - Berk, John L.

AU - Plante-Bordeneuve, Violaine

AU - Schmidt, Hartmut H.J.

AU - Merlini, Giampaolo

PY - 2015

Y1 - 2015

N2 - Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.

AB - Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.

KW - familial amyloid cardiomyopathy

KW - familial amyloid polyneuropathy

KW - genetics

KW - liver transplantation

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AN - SCOPUS:84961062552

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JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

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ER -

Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

Abstract

Keywords

ASJC Scopus subject areas

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