TY - JOUR
T1 - Diagnosis of prosthetic joint infection by use of PCR-electrospray ionization mass spectrometry
AU - Greenwood-Quaintance, Kerryl E.
AU - Uhl, James R.
AU - Hanssen, Arlen D.
AU - Sampath, Rangarajan
AU - Mandrekar, Jayawant N.
AU - Patel, Robin
PY - 2014/2
Y1 - 2014/2
N2 - We compared PCR-electrospray ionization mass spectrometry (PCR-ESI/MS) to culture using sonicate fluid from 431 subjects with explanted knee (n=270) or hip (n=161) prostheses. Of these, 152 and 279 subjects had prosthetic joint infection (PJI) and aseptic failure, respectively. The sensitivities for detecting PJI were 77.6% for PCR-ESI/MS and 69.7% for culture (P=0.0105). The specificities were 93.5 and 99.3%, respectively (P=0.0002).
AB - We compared PCR-electrospray ionization mass spectrometry (PCR-ESI/MS) to culture using sonicate fluid from 431 subjects with explanted knee (n=270) or hip (n=161) prostheses. Of these, 152 and 279 subjects had prosthetic joint infection (PJI) and aseptic failure, respectively. The sensitivities for detecting PJI were 77.6% for PCR-ESI/MS and 69.7% for culture (P=0.0105). The specificities were 93.5 and 99.3%, respectively (P=0.0002).
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U2 - 10.1128/JCM.03217-13
DO - 10.1128/JCM.03217-13
M3 - Article
C2 - 24478503
AN - SCOPUS:84893061975
SN - 0095-1137
VL - 52
SP - 642
EP - 649
JO - Journal of clinical microbiology
JF - Journal of clinical microbiology
IS - 2
ER -