Diagnosis of prosthetic joint infection by use of PCR-electrospray ionization mass spectrometry

Kerryl E. Greenwood-Quaintance, James R. Uhl, Arlen D. Hanssen, Rangarajan Sampath, Jayawant N. Mandrekar, Robin Patel

Research output: Contribution to journalArticle

25 Scopus citations


We compared PCR-electrospray ionization mass spectrometry (PCR-ESI/MS) to culture using sonicate fluid from 431 subjects with explanted knee (n=270) or hip (n=161) prostheses. Of these, 152 and 279 subjects had prosthetic joint infection (PJI) and aseptic failure, respectively. The sensitivities for detecting PJI were 77.6% for PCR-ESI/MS and 69.7% for culture (P=0.0105). The specificities were 93.5 and 99.3%, respectively (P=0.0002).

Original languageEnglish (US)
Pages (from-to)642-649
Number of pages8
JournalJournal of clinical microbiology
Issue number2
StatePublished - Feb 1 2014


ASJC Scopus subject areas

  • Microbiology (medical)

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