Diagnosis of corticotropin-producing bronchial carcinoid tumors causing Cushing's syndrome

M. C. Leinung, William Francis Young, M. D. Whitaker, B. W. Scheithauer, V. F. Trastek, L. K. Kvols

Research output: Contribution to journalArticle

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Abstract

Cushing's syndrome due to ectopic production of adrenocorticotropic hormone (corticotropin) has been recognized for many years. Traditionally, clinicians have thought that most cases were due to lung carcinomas and that the clinical manifestations differed from those for pituitary-dependent Cushing's syndrome. We report two cases of corticotropin-producing bronchial carcinoid tumors that were clinically and biochemically indistinguishable from pituitary-dependent Cushing's syndrome. Review of the literature revealed that bronchial carcinoid tumors are the most common cause of Cushing's syndrome due to ectopic secretion of corticotropin. On biochemical and anatomic studies, they are frequently indistinguishable from pituitary-dependent Cushing's syndrome and thus may be difficult to diagnose. Inferior petrosal sinus sampling for corticotropin and computerized imaging of the chest may be the best aids in making the diagnosis.

Original languageEnglish (US)
Pages (from-to)1314-1321
Number of pages8
JournalMayo Clinic Proceedings
Volume65
Issue number10
StatePublished - 1990

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Cushing Syndrome
Carcinoid Tumor
Adrenocorticotropic Hormone
Pituitary ACTH Hypersecretion
Petrosal Sinus Sampling
Thorax
Carcinoma
Lung

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Leinung, M. C., Young, W. F., Whitaker, M. D., Scheithauer, B. W., Trastek, V. F., & Kvols, L. K. (1990). Diagnosis of corticotropin-producing bronchial carcinoid tumors causing Cushing's syndrome. Mayo Clinic Proceedings, 65(10), 1314-1321.

Diagnosis of corticotropin-producing bronchial carcinoid tumors causing Cushing's syndrome. / Leinung, M. C.; Young, William Francis; Whitaker, M. D.; Scheithauer, B. W.; Trastek, V. F.; Kvols, L. K.

In: Mayo Clinic Proceedings, Vol. 65, No. 10, 1990, p. 1314-1321.

Research output: Contribution to journalArticle

Leinung, MC, Young, WF, Whitaker, MD, Scheithauer, BW, Trastek, VF & Kvols, LK 1990, 'Diagnosis of corticotropin-producing bronchial carcinoid tumors causing Cushing's syndrome', Mayo Clinic Proceedings, vol. 65, no. 10, pp. 1314-1321.
Leinung MC, Young WF, Whitaker MD, Scheithauer BW, Trastek VF, Kvols LK. Diagnosis of corticotropin-producing bronchial carcinoid tumors causing Cushing's syndrome. Mayo Clinic Proceedings. 1990;65(10):1314-1321.
Leinung, M. C. ; Young, William Francis ; Whitaker, M. D. ; Scheithauer, B. W. ; Trastek, V. F. ; Kvols, L. K. / Diagnosis of corticotropin-producing bronchial carcinoid tumors causing Cushing's syndrome. In: Mayo Clinic Proceedings. 1990 ; Vol. 65, No. 10. pp. 1314-1321.
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