Diagnosis and treatment of multiple myeloma

S Vincent Rajkumar, Robert A. Kyle

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Multiple myeloma is a malignancy of plasma cells characterized by osteolytic bone lesions, anemia, hypercalcemia, and renal failure [1, 2]. Patients with multiple myeloma must be differentiated from those with monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (Table 33.1). Multiple myeloma accounts for 1 % of all malignant disease and slightly more than 10 % of hematologic malignancies in the United States. The annual incidence, age-adjusted to the 2000 United States population, is 4.3 per 100,000 [14]. Approximately 20,850 new cases and 11,680 myeloma deaths are estimated to occur in the United States in 2009 [15]. Multiple myeloma is slightly more common in men than in women, and is twice as common in African-Americans compared with Caucasians [16]. The median age of patients at the time of diagnosis is about 65 years; [17] only 2 % of the patients are younger than 40.

Original languageEnglish (US)
Title of host publicationNeoplastic Diseases of the Blood
PublisherSpringer New York
Pages637-663
Number of pages27
ISBN (Print)9781461437642, 1461437636, 9781461437635
DOIs
StatePublished - Nov 1 2013

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Multiple Myeloma
Monoclonal Gammopathy of Undetermined Significance
Therapeutics
Hypercalcemia
Hematologic Neoplasms
Plasma Cells
African Americans
Renal Insufficiency
Anemia
Bone and Bones
Incidence
Population
Neoplasms

Keywords

  • Multiple myeloma diagnosis
  • Multiple myeloma differential diagnosis
  • Multiple myeloma treatment

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rajkumar, S. V., & Kyle, R. A. (2013). Diagnosis and treatment of multiple myeloma. In Neoplastic Diseases of the Blood (pp. 637-663). Springer New York. https://doi.org/10.1007/978-1-4614-3764-2_33

Diagnosis and treatment of multiple myeloma. / Rajkumar, S Vincent; Kyle, Robert A.

Neoplastic Diseases of the Blood. Springer New York, 2013. p. 637-663.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rajkumar, SV & Kyle, RA 2013, Diagnosis and treatment of multiple myeloma. in Neoplastic Diseases of the Blood. Springer New York, pp. 637-663. https://doi.org/10.1007/978-1-4614-3764-2_33
Rajkumar SV, Kyle RA. Diagnosis and treatment of multiple myeloma. In Neoplastic Diseases of the Blood. Springer New York. 2013. p. 637-663 https://doi.org/10.1007/978-1-4614-3764-2_33
Rajkumar, S Vincent ; Kyle, Robert A. / Diagnosis and treatment of multiple myeloma. Neoplastic Diseases of the Blood. Springer New York, 2013. pp. 637-663
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