Diagnosis and treatment of cluster headache

David J. Capobianco, David W. Dodick

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Cluster headache is an uncommon yet distinctive neurovascular syndrome occurring in either episodic or chronic patterns. The most unique feature of cluster headache is the unmistakable circadian and circannual periodicity. The attacks are stereotypical, that is, of extreme intensity, of short duration, occurring unilaterally, and associated with robust signs and symptoms of autonomic dysfunction. Unlike migraine, during an attack the patient with cluster headache often paces about. Attacks frequently occur at night, awakening the patient from sleep. Although the pathophysiology of cluster headache remains to be fully elucidated, several seminal observations have recently been made. The medical treatment of cluster headache includes acute, transitional, and maintenance prophylaxis. Agents used for acute therapy include inhalation of oxygen and triptans, such as sumatriptan, and dihydroergotamine. Transitional prophylaxis refers to the short-term use of fast-acting agents. This typically involves either corticosteroids or ergotamine derivatives. The mainstay of prophylactic therapy is verapamil. Lithium, divalproex sodium, or topiramate may also be useful. As the sophistication of functional neuroimaging increases, so too will our ability to better understand the anatomic and metabolic perturbations that underlie cluster headache.

Original languageEnglish (US)
Pages (from-to)242-259
Number of pages18
JournalSeminars in Neurology
Volume26
Issue number2
DOIs
StatePublished - Apr 1 2006

Keywords

  • Cluster headache
  • Hypothalamus
  • Transitional prophylaxis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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