Diadenosine-hexaphosphate is an inhibitory ligand of myocardial ATP-sensitive K+ channels

Aleksandar Jovanović; Andre Terzic

doi:10.1016/0014-2999(95)00611-N

Diadenosine-hexaphosphate is an inhibitory ligand of myocardial ATP-sensitive K⁺ channels

Aleksandar Jovanović, Andre Terzic

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

P¹P⁶-di(adenosine-5′)hexaphosphate (Ap₆A) has been recently demonstrated in mammalian cells, yet its function remains unknown. Using single-channel current recordings, we studied the effect of Ap₆A on guinea-pig cardiac ATP-sensitive K⁺ (K_ATP) channels. When applied to the intracellular side of excised membrane patches, Ap₆A produced a concentration-dependent inhibition (half-maximal inhibitory concentration: 14 μM; Hill coefficient: 1.1) of K_ATP channel activity. We conclude that Ap₆A is a potent inhibitory ligand of K_ATP channels.

Original language	English (US)
Pages (from-to)	R1-R2
Journal	European Journal of Pharmacology
Volume	286
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(95)00611-N
State	Published - Nov 3 1995

Keywords

ATP-sensitive K channel
Diadenosine hexaphosphate
Heart

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(95)00611-N

Cite this

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title = "Diadenosine-hexaphosphate is an inhibitory ligand of myocardial ATP-sensitive K+ channels",

abstract = "P1P6-di(adenosine-5′)hexaphosphate (Ap6A) has been recently demonstrated in mammalian cells, yet its function remains unknown. Using single-channel current recordings, we studied the effect of Ap6A on guinea-pig cardiac ATP-sensitive K+ (KATP) channels. When applied to the intracellular side of excised membrane patches, Ap6A produced a concentration-dependent inhibition (half-maximal inhibitory concentration: 14 μM; Hill coefficient: 1.1) of KATP channel activity. We conclude that Ap6A is a potent inhibitory ligand of KATP channels.",

keywords = "ATP-sensitive K channel, Diadenosine hexaphosphate, Heart",

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T1 - Diadenosine-hexaphosphate is an inhibitory ligand of myocardial ATP-sensitive K+ channels

AU - Jovanović, Aleksandar

AU - Terzic, Andre

PY - 1995/11/3

Y1 - 1995/11/3

N2 - P1P6-di(adenosine-5′)hexaphosphate (Ap6A) has been recently demonstrated in mammalian cells, yet its function remains unknown. Using single-channel current recordings, we studied the effect of Ap6A on guinea-pig cardiac ATP-sensitive K+ (KATP) channels. When applied to the intracellular side of excised membrane patches, Ap6A produced a concentration-dependent inhibition (half-maximal inhibitory concentration: 14 μM; Hill coefficient: 1.1) of KATP channel activity. We conclude that Ap6A is a potent inhibitory ligand of KATP channels.

AB - P1P6-di(adenosine-5′)hexaphosphate (Ap6A) has been recently demonstrated in mammalian cells, yet its function remains unknown. Using single-channel current recordings, we studied the effect of Ap6A on guinea-pig cardiac ATP-sensitive K+ (KATP) channels. When applied to the intracellular side of excised membrane patches, Ap6A produced a concentration-dependent inhibition (half-maximal inhibitory concentration: 14 μM; Hill coefficient: 1.1) of KATP channel activity. We conclude that Ap6A is a potent inhibitory ligand of KATP channels.

KW - ATP-sensitive K channel

KW - Diadenosine hexaphosphate

KW - Heart

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