Diadenosine-hexaphosphate is an inhibitory ligand of myocardial ATP-sensitive K+ channels

Aleksandar Jovanović, Andre Terzic

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

P1P6-di(adenosine-5′)hexaphosphate (Ap6A) has been recently demonstrated in mammalian cells, yet its function remains unknown. Using single-channel current recordings, we studied the effect of Ap6A on guinea-pig cardiac ATP-sensitive K+ (KATP) channels. When applied to the intracellular side of excised membrane patches, Ap6A produced a concentration-dependent inhibition (half-maximal inhibitory concentration: 14 μM; Hill coefficient: 1.1) of KATP channel activity. We conclude that Ap6A is a potent inhibitory ligand of KATP channels.

Original languageEnglish (US)
Pages (from-to)R1-R2
JournalEuropean Journal of Pharmacology
Volume286
Issue number1
DOIs
StatePublished - Nov 3 1995

Keywords

  • ATP-sensitive K channel
  • Diadenosine hexaphosphate
  • Heart

ASJC Scopus subject areas

  • Pharmacology

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