"Diabetic mastopathy," or sclerosing lymphocytic lobulitis, is strongly associated with type 1 diabetes.

Yogish C Kudva, Carol Reynolds, Timothy O'Brien, Claudia Powell, Ann L Oberg, Thomas B. Crotty

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To demonstrate the strong association of diabetic mastopathy or sclerosing lymphocytic lobulitis with type 1 diabetes mellitus by studying appropriate control groups and to describe risk factors and natural history of the disorder. RESEARCH DESIGN AND METHODS: This was a retrospective cross-sectional study of four groups of patients conducted at a setting tertiary care medical center. We examined benign breast biopsies (investigator masked to identity) from age-matched patients with types 1 and 2 diabetes, autoimmune thyroid disease, or none of the above disorders for sclerosing lymphocytic lobulitis. Several risk factors proposed for the disorder (age at diagnosis of benign breast disease, duration of diabetes, age at onset of diabetes, prevalence of retinopathy, neuropathy, nephropathy and cheiroarthropathy, glycemic control, parity, oral contraceptive use, menopausal status, or number of breast biopsies) were evaluated, and patients were contacted to describe the natural history of the disorder. RESULTS: Sclerosing lymphocytic lobulitis was identified in 69.7% of the subjects with type 1 diabetes and 1.8% of those with autoimmune thyroid disease diagnosed with benign breast disease at surgery. It did not occur in patients with type 2 diabetes with or without insulin treatment or in control subjects. Only retinopathy and peripheral neuropathy were associated with sclerosing lymphocytic lobulitis. Breast carcinoma or lymphoma did not occur subsequently in any type 1 diabetes patient with or without sclerosing lymphocytic lobulitis. CONCLUSIONS: Sclerosing lymphocytic lobulitis is strongly associated with type 1 diabetes. Retinopathy and neuropathy are associated with the disorder. The risk of malignancy is not increased.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalDiabetes Care
Volume25
Issue number1
StatePublished - Jan 2002

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Type 1 Diabetes Mellitus
Breast Diseases
Thyroid Diseases
Natural History
Type 2 Diabetes Mellitus
Autoimmune Diseases
Breast
Biopsy
Peripheral Nervous System Diseases
Oral Contraceptives
Parity
Age of Onset
Tertiary Care Centers
Sclerosing lymphocytic lobulitis
Lymphoma
Research Design
Cross-Sectional Studies
Research Personnel
Insulin
Breast Neoplasms

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

"Diabetic mastopathy," or sclerosing lymphocytic lobulitis, is strongly associated with type 1 diabetes. / Kudva, Yogish C; Reynolds, Carol; O'Brien, Timothy; Powell, Claudia; Oberg, Ann L; Crotty, Thomas B.

In: Diabetes Care, Vol. 25, No. 1, 01.2002, p. 121-126.

Research output: Contribution to journalArticle

Kudva, Yogish C ; Reynolds, Carol ; O'Brien, Timothy ; Powell, Claudia ; Oberg, Ann L ; Crotty, Thomas B. / "Diabetic mastopathy," or sclerosing lymphocytic lobulitis, is strongly associated with type 1 diabetes. In: Diabetes Care. 2002 ; Vol. 25, No. 1. pp. 121-126.
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