Diabetes Mellitus and Risk of Skeletal Fracture

David C. Klonoff, John H. Karam, Richard B. Mazess, Hunter Heath, L. Joseph Melton

Research output: Contribution to journalLetter

5 Scopus citations


To the Editor: Heath et al. report in the September 4 issue that medial malleolar fractures occur with increased frequency in diabetic patients. The authors could find no other bones susceptible to increased risk of fracture (and, in fact, a significantly lower overall incidence of fractures was reported in their diabetic group [P<0.05]). We propose that obesity, which has been described as a risk factor for ankle fractures,1 accounts for this susceptibility among the diabetic and pre-diabetic populations studied. The prevalence of obesity among patients with adult-onset diabetes is as high as 30 to 50 per cent2; in the.

Original languageEnglish (US)
Pages (from-to)115-116
Number of pages2
JournalNew England Journal of Medicine
Issue number2
StatePublished - Jan 8 1981

ASJC Scopus subject areas

  • Medicine(all)

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    Klonoff, D. C., Karam, J. H., Mazess, R. B., Heath, H., & Melton, L. J. (1981). Diabetes Mellitus and Risk of Skeletal Fracture. New England Journal of Medicine, 304(2), 115-116. https://doi.org/10.1056/NEJM198101083040212