Development of a Survival Score for Patients with Cerebral Metastases from Melanoma

Lena Sehmisch, Steven E. Schild, Dirk Rades

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background/Aim: To develop a survival score for patients receiving whole-brain irradiation (WBI) alone for cerebral metastases from melanoma. Patients and Methods: Forty-five patients who met the required criteria were included. WBI doses had to be >30 Gy. Six variables were analyzed: age, gender, Karnofsky performance score (KPS), number of cerebral metastases, extracranial metastatic spread and interval from diagnosis of melanoma until WBI. In order to estimate patients' survival scores, variables showing at least a trend (p<0.06) on multivariate analysis were considered. One point was assigned to each variable correlating with better survival rates and zero points to those correlating with worse survival rates. Results: By multivariate analysis, age (p=0.002) achieved significance and KPS (p=0.056) showed a trend. Patients' survival scores were obtained by adding zero or one point from each variable and resulted in three groups of 0, 1 or 2 points. The median survival times of these groups were one, four and ten months (p<0.0001). Conclusion: A survival score was developed for patients assigned to WBI alone for cerebral metastases from melanoma. This new instrument may facilitate the decision for the appropriate WBI-program.

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalAnticancer Research
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Cerebral metastases
  • Melanoma
  • Survival score
  • Treatment selection
  • Whole-brain irradiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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