Development of a Novel Self-Crosslinkable poly(caprolactone fumarate) as a Biodegradable and Injectable Scaffold for Bone Tissue Engineering

E. Jabbari, J. A. Gruetzmacher, Lichun Lu, B. L. Currier, Michael J Yaszemski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

A novel self-crosslinkable and biodegradable macromer has been developed for guided bone regeneration. This macromer is a copolymer of fumaryl chloride, which contains double bonds for in situ crosslinking, and poly(ε-caprolactone) that has a flexible chain to facilitate self-crosslinkability. This novel poly(caprolactone fumarate) (PCLF) was characterized with Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and gel permeation chromatography. Porous scaffolds were fabricated with sodium chloride particles as the porogen and a chemical initiation system. The PCLF scaffolds were characterized with scanning electron microscopy and micro-computed tomography. The PCLF copolymer was successfully self-crosslinked without the use of a crosslinking agent. This novel copolymer is potentially useful as an injectable self-crosslinkable material to treat skeletal defects.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
EditorsR.S. Leder
Pages1219-1222
Number of pages4
Volume2
StatePublished - 2003
EventA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003

Other

OtherA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryMexico
CityCancun
Period9/17/039/21/03

Fingerprint

Scaffolds (biology)
Tissue engineering
Bone
Copolymers
Scaffolds
Crosslinking
Gel permeation chromatography
Sodium chloride
Sodium Chloride
Nuclear magnetic resonance spectroscopy
Fourier transform infrared spectroscopy
Tomography
Defects
Scanning electron microscopy
poly(caprolactone fumarate)

Keywords

  • Biodegradable
  • Scaffold
  • Self-crosslinkable

ASJC Scopus subject areas

  • Bioengineering

Cite this

Jabbari, E., Gruetzmacher, J. A., Lu, L., Currier, B. L., & Yaszemski, M. J. (2003). Development of a Novel Self-Crosslinkable poly(caprolactone fumarate) as a Biodegradable and Injectable Scaffold for Bone Tissue Engineering. In R. S. Leder (Ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2, pp. 1219-1222)

Development of a Novel Self-Crosslinkable poly(caprolactone fumarate) as a Biodegradable and Injectable Scaffold for Bone Tissue Engineering. / Jabbari, E.; Gruetzmacher, J. A.; Lu, Lichun; Currier, B. L.; Yaszemski, Michael J.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. ed. / R.S. Leder. Vol. 2 2003. p. 1219-1222.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jabbari, E, Gruetzmacher, JA, Lu, L, Currier, BL & Yaszemski, MJ 2003, Development of a Novel Self-Crosslinkable poly(caprolactone fumarate) as a Biodegradable and Injectable Scaffold for Bone Tissue Engineering. in RS Leder (ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, pp. 1219-1222, A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 9/17/03.
Jabbari E, Gruetzmacher JA, Lu L, Currier BL, Yaszemski MJ. Development of a Novel Self-Crosslinkable poly(caprolactone fumarate) as a Biodegradable and Injectable Scaffold for Bone Tissue Engineering. In Leder RS, editor, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2. 2003. p. 1219-1222
Jabbari, E. ; Gruetzmacher, J. A. ; Lu, Lichun ; Currier, B. L. ; Yaszemski, Michael J. / Development of a Novel Self-Crosslinkable poly(caprolactone fumarate) as a Biodegradable and Injectable Scaffold for Bone Tissue Engineering. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. editor / R.S. Leder. Vol. 2 2003. pp. 1219-1222
@inproceedings{c9c955f88fcf4289b30f9f84b5f3555b,
title = "Development of a Novel Self-Crosslinkable poly(caprolactone fumarate) as a Biodegradable and Injectable Scaffold for Bone Tissue Engineering",
abstract = "A novel self-crosslinkable and biodegradable macromer has been developed for guided bone regeneration. This macromer is a copolymer of fumaryl chloride, which contains double bonds for in situ crosslinking, and poly(ε-caprolactone) that has a flexible chain to facilitate self-crosslinkability. This novel poly(caprolactone fumarate) (PCLF) was characterized with Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and gel permeation chromatography. Porous scaffolds were fabricated with sodium chloride particles as the porogen and a chemical initiation system. The PCLF scaffolds were characterized with scanning electron microscopy and micro-computed tomography. The PCLF copolymer was successfully self-crosslinked without the use of a crosslinking agent. This novel copolymer is potentially useful as an injectable self-crosslinkable material to treat skeletal defects.",
keywords = "Biodegradable, Scaffold, Self-crosslinkable",
author = "E. Jabbari and Gruetzmacher, {J. A.} and Lichun Lu and Currier, {B. L.} and Yaszemski, {Michael J}",
year = "2003",
language = "English (US)",
volume = "2",
pages = "1219--1222",
editor = "R.S. Leder",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

}

TY - GEN

T1 - Development of a Novel Self-Crosslinkable poly(caprolactone fumarate) as a Biodegradable and Injectable Scaffold for Bone Tissue Engineering

AU - Jabbari, E.

AU - Gruetzmacher, J. A.

AU - Lu, Lichun

AU - Currier, B. L.

AU - Yaszemski, Michael J

PY - 2003

Y1 - 2003

N2 - A novel self-crosslinkable and biodegradable macromer has been developed for guided bone regeneration. This macromer is a copolymer of fumaryl chloride, which contains double bonds for in situ crosslinking, and poly(ε-caprolactone) that has a flexible chain to facilitate self-crosslinkability. This novel poly(caprolactone fumarate) (PCLF) was characterized with Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and gel permeation chromatography. Porous scaffolds were fabricated with sodium chloride particles as the porogen and a chemical initiation system. The PCLF scaffolds were characterized with scanning electron microscopy and micro-computed tomography. The PCLF copolymer was successfully self-crosslinked without the use of a crosslinking agent. This novel copolymer is potentially useful as an injectable self-crosslinkable material to treat skeletal defects.

AB - A novel self-crosslinkable and biodegradable macromer has been developed for guided bone regeneration. This macromer is a copolymer of fumaryl chloride, which contains double bonds for in situ crosslinking, and poly(ε-caprolactone) that has a flexible chain to facilitate self-crosslinkability. This novel poly(caprolactone fumarate) (PCLF) was characterized with Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and gel permeation chromatography. Porous scaffolds were fabricated with sodium chloride particles as the porogen and a chemical initiation system. The PCLF scaffolds were characterized with scanning electron microscopy and micro-computed tomography. The PCLF copolymer was successfully self-crosslinked without the use of a crosslinking agent. This novel copolymer is potentially useful as an injectable self-crosslinkable material to treat skeletal defects.

KW - Biodegradable

KW - Scaffold

KW - Self-crosslinkable

UR - http://www.scopus.com/inward/record.url?scp=1542361550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542361550&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:1542361550

VL - 2

SP - 1219

EP - 1222

BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

A2 - Leder, R.S.

ER -