Development of a Novel Self-Crosslinkable poly(caprolactone fumarate) as a Biodegradable and Injectable Scaffold for Bone Tissue Engineering

E. Jabbari, J. A. Gruetzmacher, L. Lu, B. L. Currier, M. J. Yaszemski

Research output: Contribution to journalConference article

8 Scopus citations

Abstract

A novel self-crosslinkable and biodegradable macromer has been developed for guided bone regeneration. This macromer is a copolymer of fumaryl chloride, which contains double bonds for in situ crosslinking, and poly(ε-caprolactone) that has a flexible chain to facilitate self-crosslinkability. This novel poly(caprolactone fumarate) (PCLF) was characterized with Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and gel permeation chromatography. Porous scaffolds were fabricated with sodium chloride particles as the porogen and a chemical initiation system. The PCLF scaffolds were characterized with scanning electron microscopy and micro-computed tomography. The PCLF copolymer was successfully self-crosslinked without the use of a crosslinking agent. This novel copolymer is potentially useful as an injectable self-crosslinkable material to treat skeletal defects.

Original languageEnglish (US)
Pages (from-to)1219-1222
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
StatePublished - Dec 1 2003
EventA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003

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Keywords

  • Biodegradable
  • Scaffold
  • Self-crosslinkable

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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