An optical tweezers system has been adopted for molecular biomechanical testing. To achieve nanometer manipulation and measurement, the system was modified with a piezo-stage and an interferometer. A systematic calibration was then performed on the displacement resolution. The results revealed that the system has a nanometer resolution which is sufficient for the measurement of deformation and stiffness of single macro-molecules.
|Original language||English (US)|
|Number of pages||2|
|Journal||American Society of Mechanical Engineers, Bioengineering Division (Publication) BED|
|State||Published - Dec 1 1998|
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