Development and calibration of a nanometer manipulation and measurement system for molecular biomechanical testing

Zong Ping Luo, Kai Nan An

Research output: Contribution to journalArticle


An optical tweezers system has been adopted for molecular biomechanical testing. To achieve nanometer manipulation and measurement, the system was modified with a piezo-stage and an interferometer. A systematic calibration was then performed on the displacement resolution. The results revealed that the system has a nanometer resolution which is sufficient for the measurement of deformation and stiffness of single macro-molecules.

Original languageEnglish (US)
Pages (from-to)221-222
Number of pages2
JournalAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
StatePublished - Dec 1 1998


ASJC Scopus subject areas

  • Engineering(all)

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