Developing a Clinico-Molecular Test for Individualized Treatment of Ovarian Cancer: The interplay of Precision Medicine Informatics with Clinical and Health Economics Dimensions

Boris Winterhoff, Stefan Kommoss, Florian Heitz, Gottfried E. Konecny, Sean C. Dowdy, Sally A. Mullany, Tjoung Won Park-Simon, Klaus Baumann, Felix Hilpert, Sara Brucker, Andreas du Bois, Willibald Schröder, Alexander Burges, Steven Shen, Jinhua Wang, Roshan Tourani, Sisi Ma, Jacobus Pfisterer, Constantin F. Aliferis

Research output: Contribution to journalArticle

Abstract

We report recent progress in the development of a precision test for individualized use of the VEGF-A targeting drug bevacizumab for treating ovarian cancer. We discuss the discovery model stage (i.e., past feasibility modeling and before conversion to the production test). Main results: (a) Informatics modeling plays a critical role in supporting driving clinical and health economic requirements. (b) The novel computational models support the creation of a precision test with sufficient predictivity to reduce healthcare system costs up to $30 billion over 10 years, and make the use of bevacizumab affordable without loss of length or quality of life.

Original languageEnglish (US)
Pages (from-to)1093-1102
Number of pages10
JournalAMIA ... Annual Symposium proceedings. AMIA Symposium
Volume2018
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Winterhoff, B., Kommoss, S., Heitz, F., Konecny, G. E., Dowdy, S. C., Mullany, S. A., Park-Simon, T. W., Baumann, K., Hilpert, F., Brucker, S., du Bois, A., Schröder, W., Burges, A., Shen, S., Wang, J., Tourani, R., Ma, S., Pfisterer, J., & Aliferis, C. F. (2018). Developing a Clinico-Molecular Test for Individualized Treatment of Ovarian Cancer: The interplay of Precision Medicine Informatics with Clinical and Health Economics Dimensions. AMIA ... Annual Symposium proceedings. AMIA Symposium, 2018, 1093-1102.