Deterministic splitting of fluid volumes in electrowetting microfluidics

Ananda Banerjee, Yuguang Liu, Jason Heikenfeld, Ian Papautsky

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Conventional droplet generation approaches in digital microfluidics show ∼10% variation in droplet volumes and are restricted to creating only small volumes. In this work, we demonstrate a new approach for splitting sample volumes precisely by gradually ramping down voltage, in place of abruptly switching off electrodes. This allows us to eliminate hydrodynamic instabilities responsible for variations in droplet volume. A simple visual method was developed for measuring sample volumes created on-chip. Our results show that generating and measuring arbitrary sample volumes accurately, with < 1% variation, is possible in electrowetting devices. The approach can be easily extended to existing digital microfluidic systems, and can potentially improve performance of applications requiring precise sample metering, such as immunoassays or DNA amplification.

Original languageEnglish (US)
Pages (from-to)5138-5141
Number of pages4
JournalLab on a Chip
Volume12
Issue number24
DOIs
StatePublished - Dec 21 2012

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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