Determination of vagal baroreflex sensitivity in normal subjects

Naoki Wada, Wolfgang Singer, Tonette L. Gehrking, David M. Sletten, James D. Schmelzer, Mikihiro Kihara, Phillip A. Low

Research output: Contribution to journalArticle

5 Scopus citations


Introduction: The Valsalva maneuver (VM) is used widely to quantify the sensitivity of the vagal baroreflex loop (vagal baroreflex sensitivity, BRS_v), but most studies have focused on the heart rate (HR) response to blood pressure (BP) decrement (BRS_v↓), even though the subsequent response to an increment in BP after the VM (BRS_v↑) is important and different. Methods: We evaluated recordings of HR and BP in 187 normal subjects during the VM and determined both BRS_v↑, as determined by relating HR to the BP increase after phase III and BRS_v↓. Results: BRS_v↑ was related inversely to age. In addition, BRS_v↓, age, and magnitude of phase IV were independent predictors of BRS_v↑ in a multivariate model, accounting for 47% of the variance of BRS_v↑. Conclusions: The results indicate that both BRS_v↑ and BRS_v↓ become blunted with increasing age and that these indices relate to each other.

Original languageEnglish (US)
Pages (from-to)535-540
Number of pages6
JournalMuscle and Nerve
Issue number4
StatePublished - Oct 1 2014


  • Age
  • Baroreflex sensitivity
  • Blood pressure
  • Normal subject
  • Valsalva maneuver

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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  • Cite this

    Wada, N., Singer, W., Gehrking, T. L., Sletten, D. M., Schmelzer, J. D., Kihara, M., & Low, P. A. (2014). Determination of vagal baroreflex sensitivity in normal subjects. Muscle and Nerve, 50(4), 535-540.