Determination of vagal baroreflex sensitivity in normal subjects

Naoki Wada, Wolfgang Singer, Tonette L. Gehrking, David M. Sletten, James D. Schmelzer, Mikihiro Kihara, Phillip Anson Low

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

METHODS: We evaluated recordings of HR and BP in 187 normal subjects during the VM and determined both BRS_v↑, as determined by relating HR to the BP increase after phase III and BRS_v↓.

INTRODUCTION: The Valsalva maneuver (VM) is used widely to quantify the sensitivity of the vagal baroreflex loop (vagal baroreflex sensitivity, BRS_v), but most studies have focused on the heart rate (HR) response to blood pressure (BP) decrement (BRS_v↓), even though the subsequent response to an increment in BP after the VM (BRS_v↑) is important and different.

RESULTS: BRS_v↑ was related inversely to age. In addition, BRS_v↓, age, and magnitude of phase IV were independent predictors of BRS_v↑ in a multivariate model, accounting for 47% of the variance of BRS_v↑.

CONCLUSIONS: The results indicate that both BRS_v↑ and BRS_v↓ become blunted with increasing age and that these indices relate to each other.

Original languageEnglish (US)
Pages (from-to)535-540
Number of pages6
JournalMuscle & nerve
Volume50
Issue number4
DOIs
StatePublished - Oct 1 2014

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Baroreflex
Valsalva Maneuver
Blood Pressure
Heart Rate

Keywords

  • age
  • baroreflex sensitivity
  • blood pressure
  • normal subject
  • Valsalva maneuver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wada, N., Singer, W., Gehrking, T. L., Sletten, D. M., Schmelzer, J. D., Kihara, M., & Low, P. A. (2014). Determination of vagal baroreflex sensitivity in normal subjects. Muscle & nerve, 50(4), 535-540. https://doi.org/10.1002/mus.24191

Determination of vagal baroreflex sensitivity in normal subjects. / Wada, Naoki; Singer, Wolfgang; Gehrking, Tonette L.; Sletten, David M.; Schmelzer, James D.; Kihara, Mikihiro; Low, Phillip Anson.

In: Muscle & nerve, Vol. 50, No. 4, 01.10.2014, p. 535-540.

Research output: Contribution to journalArticle

Wada, N, Singer, W, Gehrking, TL, Sletten, DM, Schmelzer, JD, Kihara, M & Low, PA 2014, 'Determination of vagal baroreflex sensitivity in normal subjects', Muscle & nerve, vol. 50, no. 4, pp. 535-540. https://doi.org/10.1002/mus.24191
Wada N, Singer W, Gehrking TL, Sletten DM, Schmelzer JD, Kihara M et al. Determination of vagal baroreflex sensitivity in normal subjects. Muscle & nerve. 2014 Oct 1;50(4):535-540. https://doi.org/10.1002/mus.24191
Wada, Naoki ; Singer, Wolfgang ; Gehrking, Tonette L. ; Sletten, David M. ; Schmelzer, James D. ; Kihara, Mikihiro ; Low, Phillip Anson. / Determination of vagal baroreflex sensitivity in normal subjects. In: Muscle & nerve. 2014 ; Vol. 50, No. 4. pp. 535-540.
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