TY - JOUR
T1 - Determinants of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in house dust samples from four areas of the United States
AU - Deziel, N. C.
AU - Nuckols, J. R.
AU - Colt, J. S.
AU - De Roos, A. J.
AU - Pronk, A.
AU - Gourley, C.
AU - Severson, R. K.
AU - Cozen, W.
AU - Cerhan, J. R.
AU - Hartge, P.
AU - Ward, M. H.
N1 - Funding Information:
This study was supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health ; NCI-Iowa SEER contract N01-CN-67008 ; NCI-Los Angeles County SEER contract N01-CN-67010 ; NCI-Seattle SEER contract N01-PC-67009 ; and NCI-Detroit SEER contract N01-PC-65064 . Dr. John Nuckols was supported, in part, through an intergovernmental personnel agreement between the NCI Occupational and Environmental Epidemiology Branch and Colorado State University . We thank Mr. Matt Airola of Westat for GIS support, Ms. Lonn Irish of Information Management Systems, Inc. for programming support, and all the study staff and participants.
PY - 2012/9/1
Y1 - 2012/9/1
N2 - Determinants of levels of polychlorinated dibenzo- p-dioxins and polychlorinated dibenzofurans (PCDD/F) in dust in U.S. homes are not well characterized. We conducted a pilot study to evaluate the relationship between concentrations of PCDD/F in house dust and residential proximity to known sources, including industrial facilities and traffic. Samples from vacuum bag dust from homes of 40 residents of Detroit, Los Angeles, Seattle, or Iowa who participated in a population-based case-control study of non-Hodgkin lymphoma conducted in 1998-2000 were analyzed using high resolution gas chromatography/high resolution mass spectrometry for 7 PCDD and 10 PCDF congeners considered toxic by the U.S. Environmental Protection Agency (EPA). Locations of 10 types of PCDD/F-emitting facilities were obtained from the EPA; however only 4 types were located near study homes (non-hazardous waste cement kilns, coal-fired power plants, sewage sludge incinerators, and medical waste incinerators). Relationships between concentrations of each PCDD/F and proximity to industrial facilities, freight routes, and major roads were evaluated using separate multivariate regression models for each congener. The median (inter-quartile range [IQR]) toxic equivalence (TEQ) concentration of these congeners in the house dust was 20.3. pg/g (IQR = 14.3, 32.7). Homes within 3 or 5. km of a cement kiln had 2 to 9-fold higher concentrations of 5 PCDD and 5 PCDF (p < 0.1 in each model). Proximity to freight routes and major roads was associated with elevated concentrations of 1 PCDD and 8 PCDF. Higher concentrations of certain PCDD/F in homes near cement kilns, freight routes, and major roads suggest that these outdoor sources are contributing to indoor environmental exposures. Further study of the contribution of these sources and other facility types to total PCDD/F exposure in a larger number of homes is warranted.
AB - Determinants of levels of polychlorinated dibenzo- p-dioxins and polychlorinated dibenzofurans (PCDD/F) in dust in U.S. homes are not well characterized. We conducted a pilot study to evaluate the relationship between concentrations of PCDD/F in house dust and residential proximity to known sources, including industrial facilities and traffic. Samples from vacuum bag dust from homes of 40 residents of Detroit, Los Angeles, Seattle, or Iowa who participated in a population-based case-control study of non-Hodgkin lymphoma conducted in 1998-2000 were analyzed using high resolution gas chromatography/high resolution mass spectrometry for 7 PCDD and 10 PCDF congeners considered toxic by the U.S. Environmental Protection Agency (EPA). Locations of 10 types of PCDD/F-emitting facilities were obtained from the EPA; however only 4 types were located near study homes (non-hazardous waste cement kilns, coal-fired power plants, sewage sludge incinerators, and medical waste incinerators). Relationships between concentrations of each PCDD/F and proximity to industrial facilities, freight routes, and major roads were evaluated using separate multivariate regression models for each congener. The median (inter-quartile range [IQR]) toxic equivalence (TEQ) concentration of these congeners in the house dust was 20.3. pg/g (IQR = 14.3, 32.7). Homes within 3 or 5. km of a cement kiln had 2 to 9-fold higher concentrations of 5 PCDD and 5 PCDF (p < 0.1 in each model). Proximity to freight routes and major roads was associated with elevated concentrations of 1 PCDD and 8 PCDF. Higher concentrations of certain PCDD/F in homes near cement kilns, freight routes, and major roads suggest that these outdoor sources are contributing to indoor environmental exposures. Further study of the contribution of these sources and other facility types to total PCDD/F exposure in a larger number of homes is warranted.
KW - Dioxins
KW - Dust
KW - Environmental exposure
KW - Furans
KW - Geographic information systems
KW - Non-Hodgkin lymphoma (NHL)
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U2 - 10.1016/j.scitotenv.2012.06.098
DO - 10.1016/j.scitotenv.2012.06.098
M3 - Article
C2 - 22832089
AN - SCOPUS:84864051965
SN - 0048-9697
VL - 433
SP - 516
EP - 522
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -