Detection of human pathogenic Ehrlichia muris-like agent in Peromyscus leucopus

Caroline G. Castillo, Marina E. Eremeeva, Susan M. Paskewitz, Lynne M. Sloan, Xia Lee, William E. Irwin, Stefan Tonsberg, Bobbi S. Pritt

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

An Ehrlichia muris-like (EML) bacterium was recently detected in humans and Ixodes scapularis ticks in Minnesota and Wisconsin. The reservoir for this agent is unknown. To investigate the occurrence of the EML agent, groEL PCR testing and sequencing was performed on blood from small mammals and white-tailed deer that were collected in areas where human and tick infections were previously demonstrated. DNA of the EML agent was detected in two Peromyscus leucopus of 146 small mammals (1.4%); while 181 O. virginianus tested negative. This report provides the first evidence that DNA from the EML agent is found in P. leucopus, the same animal that is a reservoir for Anaplasma phagocytophilum in this region. The role of white-tailed deer remains inconclusive. Further sampling is warranted to understand the spatial and temporal distribution, transmission and maintenance of this pathogen.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalTicks and Tick-borne Diseases
Volume6
Issue number2
DOIs
StatePublished - Mar 1 2015

Fingerprint

Ehrlichia muris
Ehrlichia
Peromyscus
Peromyscus leucopus
Deer
Ticks
Odocoileus virginianus
small mammals
ticks
Mammals
Anaplasma phagocytophilum
Ixodes
Ixodes scapularis
Infectious Disease Transmission
DNA
Maintenance
Bacteria
Polymerase Chain Reaction
pathogens
bacteria

Keywords

  • Ehrlichia muris
  • Ehrlichia muris-like (EML) agent
  • Ehrlichiosis
  • Peromyscus

ASJC Scopus subject areas

  • Infectious Diseases
  • Insect Science
  • Parasitology
  • Microbiology
  • Medicine(all)

Cite this

Castillo, C. G., Eremeeva, M. E., Paskewitz, S. M., Sloan, L. M., Lee, X., Irwin, W. E., ... Pritt, B. S. (2015). Detection of human pathogenic Ehrlichia muris-like agent in Peromyscus leucopus. Ticks and Tick-borne Diseases, 6(2), 155-157. https://doi.org/10.1016/j.ttbdis.2014.11.006

Detection of human pathogenic Ehrlichia muris-like agent in Peromyscus leucopus. / Castillo, Caroline G.; Eremeeva, Marina E.; Paskewitz, Susan M.; Sloan, Lynne M.; Lee, Xia; Irwin, William E.; Tonsberg, Stefan; Pritt, Bobbi S.

In: Ticks and Tick-borne Diseases, Vol. 6, No. 2, 01.03.2015, p. 155-157.

Research output: Contribution to journalArticle

Castillo, CG, Eremeeva, ME, Paskewitz, SM, Sloan, LM, Lee, X, Irwin, WE, Tonsberg, S & Pritt, BS 2015, 'Detection of human pathogenic Ehrlichia muris-like agent in Peromyscus leucopus', Ticks and Tick-borne Diseases, vol. 6, no. 2, pp. 155-157. https://doi.org/10.1016/j.ttbdis.2014.11.006
Castillo CG, Eremeeva ME, Paskewitz SM, Sloan LM, Lee X, Irwin WE et al. Detection of human pathogenic Ehrlichia muris-like agent in Peromyscus leucopus. Ticks and Tick-borne Diseases. 2015 Mar 1;6(2):155-157. https://doi.org/10.1016/j.ttbdis.2014.11.006
Castillo, Caroline G. ; Eremeeva, Marina E. ; Paskewitz, Susan M. ; Sloan, Lynne M. ; Lee, Xia ; Irwin, William E. ; Tonsberg, Stefan ; Pritt, Bobbi S. / Detection of human pathogenic Ehrlichia muris-like agent in Peromyscus leucopus. In: Ticks and Tick-borne Diseases. 2015 ; Vol. 6, No. 2. pp. 155-157.
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