Abstract
The replication sites of the recently discovered hepatitis G virus (HGV) remain unknown. Using highly strand-specific Tth-based reverse transcriptase PCR, we searched for the presence of viral RNA negative strand in multiple autopsy tissues from four patients with AIDS and in peripheral blood mononuclear cells from six other human immunodeficiency virus-positive patients. Negative-strand HGV RNA was detected in three of four bone marrow samples, in two of two spleen samples, and in one of four liver tissue samples. However, the specific cellular site of replication within the positive tissues was not determined. This study does not support HGV as a primary hepatotropic virus.
Original language | English (US) |
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Pages (from-to) | 3072-3075 |
Number of pages | 4 |
Journal | Journal of virology |
Volume | 72 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1998 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology