Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy

Scott Koenig; Howard E. Gendelman; Jan M. Orenstein; Mauro C. Dal Canto; Gholam H. Pezeshkpour; Margaret Yungbluth; Frank Janotta; Allen Aksamit; Malcolm A. Martin; Anthony S. Fauci

doi:10.1126/science.3016903

Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy

Scott Koenig, Howard E. Gendelman, Jan M. Orenstein, Mauro C. Dal Canto, Gholam H. Pezeshkpour, Margaret Yungbluth, Frank Janotta, Allen Aksamit, Malcolm A. Martin, Anthony S. Fauci

Neurology

Research output: Contribution to journal › Article › peer-review

1315 Scopus citations

Abstract

One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.

Original language	English (US)
Pages (from-to)	1089-1093
Number of pages	5
Journal	Science
Volume	233
Issue number	4768
DOIs	https://doi.org/10.1126/science.3016903
State	Published - 1986

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title = "Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy",

abstract = "One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.",

author = "Scott Koenig and Gendelman, {Howard E.} and Orenstein, {Jan M.} and {Dal Canto}, {Mauro C.} and Pezeshkpour, {Gholam H.} and Margaret Yungbluth and Frank Janotta and Allen Aksamit and Martin, {Malcolm A.} and Fauci, {Anthony S.}",

year = "1986",

doi = "10.1126/science.3016903",

language = "English (US)",

volume = "233",

pages = "1089--1093",

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T1 - Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy

AU - Koenig, Scott

AU - Gendelman, Howard E.

AU - Orenstein, Jan M.

AU - Dal Canto, Mauro C.

AU - Pezeshkpour, Gholam H.

AU - Yungbluth, Margaret

AU - Janotta, Frank

AU - Aksamit, Allen

AU - Martin, Malcolm A.

AU - Fauci, Anthony S.

PY - 1986

Y1 - 1986

N2 - One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.

AB - One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.

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Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy

Abstract

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