Designing ideal conduits for peripheral nerve repair

G. C W de Ruiter, M. J A Malessy, Michael J Yaszemski, Anthony John Windebank, Robert J. Spinner

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

Nerve tubes, guides, or conduits are a promising alternative for autologous nerve graft repair. The first biodegradable empty single lumen or hollow nerve tubes are currently available for clinical use and are being used mostly in the repair of small-diameter nerves with nerve defects of < 3 cm. These nerve tubes are made of different biomaterials using various fabrication techniques. As a result these tubes also differ in physical properties. In addition, several modifications to the common hollow nerve tube (for example, the addition of Schwann cells, growth factors, and internal frameworks) are being investigated that may increase the gap that can be bridged. This combination of chemical, physical, and biological factors has made the design of a nerve conduit into a complex process that demands close collaboration of bioengineers, neuroscientists, and peripheral nerve surgeons. In this article the authors discuss the different steps that are involved in the process of the design of an ideal nerve conduit for peripheral nerve repair. (DOI: 10.3171/FOC.2009.26.2.E5).

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalNeurosurgical Focus
Volume26
Issue number2
DOIs
StatePublished - 2009

Fingerprint

Peripheral Nerves
Schwann Cells
Biological Factors
Biocompatible Materials
Intercellular Signaling Peptides and Proteins
Transplants
Surgeons

Keywords

  • Biomaterial
  • Growth factor
  • Nerve conduit
  • Nerve guide
  • Nerve tube
  • Polymer
  • Schwann cell

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Designing ideal conduits for peripheral nerve repair. / de Ruiter, G. C W; Malessy, M. J A; Yaszemski, Michael J; Windebank, Anthony John; Spinner, Robert J.

In: Neurosurgical Focus, Vol. 26, No. 2, 2009, p. 1-9.

Research output: Contribution to journalArticle

de Ruiter, G. C W ; Malessy, M. J A ; Yaszemski, Michael J ; Windebank, Anthony John ; Spinner, Robert J. / Designing ideal conduits for peripheral nerve repair. In: Neurosurgical Focus. 2009 ; Vol. 26, No. 2. pp. 1-9.
@article{94da4153ad1b488cb1bbb7056aae1024,
title = "Designing ideal conduits for peripheral nerve repair",
abstract = "Nerve tubes, guides, or conduits are a promising alternative for autologous nerve graft repair. The first biodegradable empty single lumen or hollow nerve tubes are currently available for clinical use and are being used mostly in the repair of small-diameter nerves with nerve defects of < 3 cm. These nerve tubes are made of different biomaterials using various fabrication techniques. As a result these tubes also differ in physical properties. In addition, several modifications to the common hollow nerve tube (for example, the addition of Schwann cells, growth factors, and internal frameworks) are being investigated that may increase the gap that can be bridged. This combination of chemical, physical, and biological factors has made the design of a nerve conduit into a complex process that demands close collaboration of bioengineers, neuroscientists, and peripheral nerve surgeons. In this article the authors discuss the different steps that are involved in the process of the design of an ideal nerve conduit for peripheral nerve repair. (DOI: 10.3171/FOC.2009.26.2.E5).",
keywords = "Biomaterial, Growth factor, Nerve conduit, Nerve guide, Nerve tube, Polymer, Schwann cell",
author = "{de Ruiter}, {G. C W} and Malessy, {M. J A} and Yaszemski, {Michael J} and Windebank, {Anthony John} and Spinner, {Robert J.}",
year = "2009",
doi = "10.3171/FOC.2009.26.2.E5",
language = "English (US)",
volume = "26",
pages = "1--9",
journal = "Neurosurgical Focus",
issn = "1092-0684",
publisher = "American Association of Neurological Surgeons",
number = "2",

}

TY - JOUR

T1 - Designing ideal conduits for peripheral nerve repair

AU - de Ruiter, G. C W

AU - Malessy, M. J A

AU - Yaszemski, Michael J

AU - Windebank, Anthony John

AU - Spinner, Robert J.

PY - 2009

Y1 - 2009

N2 - Nerve tubes, guides, or conduits are a promising alternative for autologous nerve graft repair. The first biodegradable empty single lumen or hollow nerve tubes are currently available for clinical use and are being used mostly in the repair of small-diameter nerves with nerve defects of < 3 cm. These nerve tubes are made of different biomaterials using various fabrication techniques. As a result these tubes also differ in physical properties. In addition, several modifications to the common hollow nerve tube (for example, the addition of Schwann cells, growth factors, and internal frameworks) are being investigated that may increase the gap that can be bridged. This combination of chemical, physical, and biological factors has made the design of a nerve conduit into a complex process that demands close collaboration of bioengineers, neuroscientists, and peripheral nerve surgeons. In this article the authors discuss the different steps that are involved in the process of the design of an ideal nerve conduit for peripheral nerve repair. (DOI: 10.3171/FOC.2009.26.2.E5).

AB - Nerve tubes, guides, or conduits are a promising alternative for autologous nerve graft repair. The first biodegradable empty single lumen or hollow nerve tubes are currently available for clinical use and are being used mostly in the repair of small-diameter nerves with nerve defects of < 3 cm. These nerve tubes are made of different biomaterials using various fabrication techniques. As a result these tubes also differ in physical properties. In addition, several modifications to the common hollow nerve tube (for example, the addition of Schwann cells, growth factors, and internal frameworks) are being investigated that may increase the gap that can be bridged. This combination of chemical, physical, and biological factors has made the design of a nerve conduit into a complex process that demands close collaboration of bioengineers, neuroscientists, and peripheral nerve surgeons. In this article the authors discuss the different steps that are involved in the process of the design of an ideal nerve conduit for peripheral nerve repair. (DOI: 10.3171/FOC.2009.26.2.E5).

KW - Biomaterial

KW - Growth factor

KW - Nerve conduit

KW - Nerve guide

KW - Nerve tube

KW - Polymer

KW - Schwann cell

UR - http://www.scopus.com/inward/record.url?scp=70349736519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349736519&partnerID=8YFLogxK

U2 - 10.3171/FOC.2009.26.2.E5

DO - 10.3171/FOC.2009.26.2.E5

M3 - Article

C2 - 19435445

AN - SCOPUS:70349736519

VL - 26

SP - 1

EP - 9

JO - Neurosurgical Focus

JF - Neurosurgical Focus

SN - 1092-0684

IS - 2

ER -