TY - JOUR
T1 - Designing exercise clinical trials for older adults with cancer
T2 - Recommendations from 2015 Cancer and Aging Research Group NCI U13 Meeting
AU - Kilari, Deepak
AU - Soto-Perez-de-Celis, Enrique
AU - Mohile, Supriya Gupta
AU - Alibhai, Shabbir M.H.
AU - Presley, Carolyn J.
AU - Wildes, Tanya M.
AU - Klepin, Heidi D.
AU - Demark-Wahnefried, Wendy
AU - Jatoi, Amina
AU - Harrison, Robert
AU - Won, Elizabeth
AU - Mustian, Karen M.
N1 - Publisher Copyright:
© 2016
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Cancer and its treatment can lead to a myriad of adverse events and negatively impact quality of life of older cancer patients and survivors. Unmet physical activity needs vary across the cancer continuum and remain an important yet understudied area of research in this population. Exercise interventions have been shown to be effective in treating both the physical and psychological declines associated with cancer and its treatment, with a potential to improve cancer-related outcomes. Despite the current evidence, exercise is clearly underutilized due to several barriers and knowledge gaps in existing trials that include appropriate population identification, design, and outcome measures selection. The benefits of regular exercise in both the primary and secondary prevention of chronic conditions are well established in the non-cancer population. In older cancer patients and survivors, further research is needed before exercise gains widespread acceptance. The Cancer and Aging Research Group convened experts in exercise, aging and cancer to evaluate current scientific evidence and knowledge gaps in geriatric exercise oncology. This report summarizes these findings and provides future research directions.
AB - Cancer and its treatment can lead to a myriad of adverse events and negatively impact quality of life of older cancer patients and survivors. Unmet physical activity needs vary across the cancer continuum and remain an important yet understudied area of research in this population. Exercise interventions have been shown to be effective in treating both the physical and psychological declines associated with cancer and its treatment, with a potential to improve cancer-related outcomes. Despite the current evidence, exercise is clearly underutilized due to several barriers and knowledge gaps in existing trials that include appropriate population identification, design, and outcome measures selection. The benefits of regular exercise in both the primary and secondary prevention of chronic conditions are well established in the non-cancer population. In older cancer patients and survivors, further research is needed before exercise gains widespread acceptance. The Cancer and Aging Research Group convened experts in exercise, aging and cancer to evaluate current scientific evidence and knowledge gaps in geriatric exercise oncology. This report summarizes these findings and provides future research directions.
KW - Cancer
KW - Exercise
KW - Geriatric recommendations
KW - Older patients
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U2 - 10.1016/j.jgo.2016.04.007
DO - 10.1016/j.jgo.2016.04.007
M3 - Review article
C2 - 27197916
AN - SCOPUS:84971268860
SN - 1879-4068
VL - 7
SP - 293
EP - 304
JO - Journal of Geriatric Oncology
JF - Journal of Geriatric Oncology
IS - 4
ER -