Designation as "unfit for open repair" is associated with poor outcomes after endovascular aortic aneurysm repair

Randall R. De Martino, Benjamin S. Brooke, William Robinson, Andres Schanzer, Jeffrey E. Indes, Jessica B. Wallaert, Brian W. Nolan, Jack L. Cronenwett, Philip P. Goodney

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background-Endovascular aortic aneurysm repair (EVAR) is often offered to patients with abdominal aortic aneurysms (AAAs) considered preoperatively to be unfit for open AAA repair (oAAA). This study describes the short- and long-term outcomes of patients undergoing EVAR with AAAs <6.5 cm who are considered unfit for oAAA. Methods and Results-We analyzed elective EVARs for AAAs <6.5 cm diameter in the Vascular Study Group of New England (2003-2011). Patients were designated as fit or unfit for oAAA by the treating surgeon. End points included inhospital major adverse events and long-term mortality. We identified patient characteristics associated with being unfit for open repair and predictors of survival using multivariable analyses. Of 1653 EVARs, 309 (18.7%) patients were deemed unfit for oAAA. These patients were more likely to have advanced age, cardiac disease, chronic obstructive pulmonary disease, and larger aneurysms at the time of repair (54 versus 56 mm, P=0.001). Patients unfit for oAAA had higher rates of cardiac (7.8% versus 3.1%, P<0.01) and pulmonary (3.6 versus 1.6, P<0.01) complications and worse survival rates at 5 years (61% versus 80%; log rank P<0.01) compared with those deemed fit for oAAA. Finally, patients designated as unfit for oAAA had worse survival, even adjusting for patient characteristics and aneurysm size (hazard ratio, 1.6; 95% confidence interval, 1.2-2.2; P<0.01). Conclusions-In patients with AAAs <6.5 cm, designation by the operating surgeon as unfit for oAAA provides insight into both short- and long-term efficacy of EVAR. Patients unable to tolerate oAAA may not benefit from EVAR unless their risk of AAA rupture is very high.

Original languageEnglish (US)
Pages (from-to)575-581
Number of pages7
JournalCirculation: Cardiovascular Quality and Outcomes
Volume6
Issue number5
DOIs
StatePublished - Sep 2013

Keywords

  • Aneurysm
  • Complications
  • Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    De Martino, R. R., Brooke, B. S., Robinson, W., Schanzer, A., Indes, J. E., Wallaert, J. B., Nolan, B. W., Cronenwett, J. L., & Goodney, P. P. (2013). Designation as "unfit for open repair" is associated with poor outcomes after endovascular aortic aneurysm repair. Circulation: Cardiovascular Quality and Outcomes, 6(5), 575-581. https://doi.org/10.1161/CIRCOUTCOMES.113.000303