Design and Verification of Novel Low-Cost MR-Guided Small-Animal Stereotactic System

Jonathan D. Plasencia, Leland S Hu, Gregory H. Turner, Kevin M. Bennett, David H. Frakes

Research output: Contribution to journalArticle

Abstract

Stereotactic systems have been used for decades to position surgical instruments in important preclinical and clinical studies. We developed and verified a low-cost magnetic-resonance-guided system for accurate preclinical stereotactic operations on small animals. The system consists of both commercially available and custom components, including in-house software written in MATLAB to register coordinate spaces. The software registers target the image-space coordinates from magnetic resonance imaging to the physical space through a rigid-body transform. The transform uses singular value decomposition to determine rotation and translation matrices that are optimal in a least squares sense. Needle positioning and core biopsy studies were performed to verify the accuracy of the system. The needle positioning study demonstrated a sub-millimeter positioning error of 0.294 ± 0.156 mm while using a 26 s gauge Hamilton needle. Biopsy studies demonstrated >94 % success in accessing sub-millimeter stereotactic targets embedded in agarose gel phantoms. These favorable results confirm that despite its relatively low hardware cost (US$18,730) and easy assembly, the system is able to consistently access stereotactic targets on the spatial scale of a small animal.

Original languageEnglish (US)
Pages (from-to)526-535
Number of pages10
JournalJournal of Medical and Biological Engineering
Volume36
Issue number4
DOIs
StatePublished - Aug 1 2016

Fingerprint

Needles
Animals
Software
Biopsy
Magnetic resonance
Large-Core Needle Biopsy
Costs and Cost Analysis
Least-Squares Analysis
Surgical Instruments
Sepharose
Costs
Magnetic Resonance Spectroscopy
Gels
Magnetic Resonance Imaging
Singular value decomposition
MATLAB
Gages
Hardware
Imaging techniques
Clinical Studies

Keywords

  • Biopsy
  • Magnetic resonance (MR)-guided
  • Magnetic resonance imaging (MRI)
  • Preclinical
  • Registration
  • Small animal
  • Stereotactic

ASJC Scopus subject areas

  • Medicine(all)
  • Biomedical Engineering

Cite this

Design and Verification of Novel Low-Cost MR-Guided Small-Animal Stereotactic System. / Plasencia, Jonathan D.; Hu, Leland S; Turner, Gregory H.; Bennett, Kevin M.; Frakes, David H.

In: Journal of Medical and Biological Engineering, Vol. 36, No. 4, 01.08.2016, p. 526-535.

Research output: Contribution to journalArticle

Plasencia, Jonathan D. ; Hu, Leland S ; Turner, Gregory H. ; Bennett, Kevin M. ; Frakes, David H. / Design and Verification of Novel Low-Cost MR-Guided Small-Animal Stereotactic System. In: Journal of Medical and Biological Engineering. 2016 ; Vol. 36, No. 4. pp. 526-535.
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