TY - JOUR
T1 - Dermatologic adverse effects of lenalidomide therapy for amyloidosis and multiple myeloma
AU - Sviggum, Hans P.
AU - Davis, Mark D.P.
AU - Rajkumar, S. Vincent
AU - Dispenzieri, Angela
PY - 2006
Y1 - 2006
N2 - Objectives: To examine dermatologic adverse effects of lenalidomide in patients with amyloidosis and multiple myeloma and to determine whether the adverse effects are different when lenalidomide is used alone compared withwhen it is used in combination with dexamethasone. Design: Retrospective review of medical records. Setting: Tertiary referral center. Patients: Seventy-five patients with multiple myeloma and 23 patients with amyloidosis participating in clinical trials. Intervention: In the 75 patients with multiple myeloma, lenalidomide was the treatment in 24 and lenalidomide and dexamethasone in 51. In the 23 patients with amyloidosis, lenalidomide was used alone. Main Outcome Measures: The frequency, type, severity, and time of onset of all skin eruptions that were temporally related to lenalidomide treatment were recorded. Results: In the patients with amyloidosis treated with lenalidomide, 10 (43%) had rashes. In the patients with multiple myeloma, rashes occurred in 7 (29%) of those receiving lenalidomide alone and in 15 (29%) of those receiving lenalidomide and dexamethasone. The rashes were characterized as morbilliform, urticarial, dermatitic, acneiform, and undefined. Severe rashes required permanent discontinuation of lenalidomide therapy in 2 patients. In 23 patients (72%), rashes occurred in the first month after therapy was initiated; however, delayed-onset rashes occurred in 9 (28%). Conclusions: The prevalence of dermatologic adverse effects in patients receiving lenalidomide was higher in those with amyloidosis than in those with multiple myeloma. The prevalence of skin eruptions was not diminished by the concurrent use of systemic corticosteroids. Most skin eruptions were mild and did not necessitate withdrawal of lenalidomide therapy.
AB - Objectives: To examine dermatologic adverse effects of lenalidomide in patients with amyloidosis and multiple myeloma and to determine whether the adverse effects are different when lenalidomide is used alone compared withwhen it is used in combination with dexamethasone. Design: Retrospective review of medical records. Setting: Tertiary referral center. Patients: Seventy-five patients with multiple myeloma and 23 patients with amyloidosis participating in clinical trials. Intervention: In the 75 patients with multiple myeloma, lenalidomide was the treatment in 24 and lenalidomide and dexamethasone in 51. In the 23 patients with amyloidosis, lenalidomide was used alone. Main Outcome Measures: The frequency, type, severity, and time of onset of all skin eruptions that were temporally related to lenalidomide treatment were recorded. Results: In the patients with amyloidosis treated with lenalidomide, 10 (43%) had rashes. In the patients with multiple myeloma, rashes occurred in 7 (29%) of those receiving lenalidomide alone and in 15 (29%) of those receiving lenalidomide and dexamethasone. The rashes were characterized as morbilliform, urticarial, dermatitic, acneiform, and undefined. Severe rashes required permanent discontinuation of lenalidomide therapy in 2 patients. In 23 patients (72%), rashes occurred in the first month after therapy was initiated; however, delayed-onset rashes occurred in 9 (28%). Conclusions: The prevalence of dermatologic adverse effects in patients receiving lenalidomide was higher in those with amyloidosis than in those with multiple myeloma. The prevalence of skin eruptions was not diminished by the concurrent use of systemic corticosteroids. Most skin eruptions were mild and did not necessitate withdrawal of lenalidomide therapy.
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U2 - 10.1001/archderm.142.10.1298
DO - 10.1001/archderm.142.10.1298
M3 - Article
C2 - 17043184
AN - SCOPUS:33750074147
SN - 0003-987X
VL - 142
SP - 1298
EP - 1302
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 10
ER -