Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation

J. S. Pulido; T. J. Flotte; H. Raja; S. Miles; J. L. Winters; R. Niles; E. A. Jaben; S. N. Markovic; J. Davies; K. R. Kalli; R. G. Vile; J. J. Garcia; D. R. Salomao

doi:10.1038/eye.2013.131

Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation

J. S. Pulido, T. J. Flotte, H. Raja, S. Miles, J. L. Winters, R. Niles, E. A. Jaben, S. N. Markovic, J. Davies, K. R. Kalli, R. G. Vile, J. J. Garcia, D. R. Salomao

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

AimThe goal of this case report is to describe the dermatologic and conjunctival findings in a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), a paraneoplastic syndrome usually associated with gynecologic cancers. There is little information about other dermatologic melanocytic findings in these patients.MethodsHistologic and fluorescent in situ hybridization (FISH) analysis of three separate skin biopsies, one of which was separated by 21 months from the others, were performed in a 71-year-old patient with BDUMP to assess for histologic and chromosomal abnormality. Conjunctival histologic evaluation was also done.ResultsDermal melanocytic proliferation was seen in each specimen. The cells were spindle type with mitotic activity. FISH analysis showed a normal copy of chromosomes. The conjunctival sample also showed normal FISH analysis.ConclusionBDUMP is associated with multifocal dermal and conjunctival melanocytic proliferation.

Original language	English (US)
Pages (from-to)	1058-1062
Number of pages	5
Journal	Eye (Basingstoke)
Volume	27
Issue number	9
DOIs	https://doi.org/10.1038/eye.2013.131
State	Published - Sep 2013

Keywords

Bilateral diffuse uveal melanocytic proliferation
Cancer
Dermal proliferation
Melanoma
Paraneoplastic syndromes
Uveal melanoma

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1038/eye.2013.131

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@article{42aa095a01e3406c92f4739469ef094a,

title = "Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation",

abstract = "AimThe goal of this case report is to describe the dermatologic and conjunctival findings in a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), a paraneoplastic syndrome usually associated with gynecologic cancers. There is little information about other dermatologic melanocytic findings in these patients.MethodsHistologic and fluorescent in situ hybridization (FISH) analysis of three separate skin biopsies, one of which was separated by 21 months from the others, were performed in a 71-year-old patient with BDUMP to assess for histologic and chromosomal abnormality. Conjunctival histologic evaluation was also done.ResultsDermal melanocytic proliferation was seen in each specimen. The cells were spindle type with mitotic activity. FISH analysis showed a normal copy of chromosomes. The conjunctival sample also showed normal FISH analysis.ConclusionBDUMP is associated with multifocal dermal and conjunctival melanocytic proliferation.",

keywords = "Bilateral diffuse uveal melanocytic proliferation, Cancer, Dermal proliferation, Melanoma, Paraneoplastic syndromes, Uveal melanoma",

author = "Pulido, {J. S.} and Flotte, {T. J.} and H. Raja and S. Miles and Winters, {J. L.} and R. Niles and Jaben, {E. A.} and Markovic, {S. N.} and J. Davies and Kalli, {K. R.} and Vile, {R. G.} and Garcia, {J. J.} and Salomao, {D. R.}",

note = "Funding Information: This study was supported in part by unrestricted grants from Research to Prevent Blindness Inc. and from Terry and Judith Paul.",

year = "2013",

month = sep,

doi = "10.1038/eye.2013.131",

language = "English (US)",

volume = "27",

pages = "1058--1062",

journal = "Eye (Basingstoke)",

issn = "0950-222X",

publisher = "Nature Publishing Group",

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T1 - Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation

AU - Pulido, J. S.

AU - Flotte, T. J.

AU - Raja, H.

AU - Miles, S.

AU - Winters, J. L.

AU - Niles, R.

AU - Jaben, E. A.

AU - Markovic, S. N.

AU - Davies, J.

AU - Kalli, K. R.

AU - Vile, R. G.

AU - Garcia, J. J.

AU - Salomao, D. R.

N1 - Funding Information: This study was supported in part by unrestricted grants from Research to Prevent Blindness Inc. and from Terry and Judith Paul.

PY - 2013/9

Y1 - 2013/9

N2 - AimThe goal of this case report is to describe the dermatologic and conjunctival findings in a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), a paraneoplastic syndrome usually associated with gynecologic cancers. There is little information about other dermatologic melanocytic findings in these patients.MethodsHistologic and fluorescent in situ hybridization (FISH) analysis of three separate skin biopsies, one of which was separated by 21 months from the others, were performed in a 71-year-old patient with BDUMP to assess for histologic and chromosomal abnormality. Conjunctival histologic evaluation was also done.ResultsDermal melanocytic proliferation was seen in each specimen. The cells were spindle type with mitotic activity. FISH analysis showed a normal copy of chromosomes. The conjunctival sample also showed normal FISH analysis.ConclusionBDUMP is associated with multifocal dermal and conjunctival melanocytic proliferation.

AB - AimThe goal of this case report is to describe the dermatologic and conjunctival findings in a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), a paraneoplastic syndrome usually associated with gynecologic cancers. There is little information about other dermatologic melanocytic findings in these patients.MethodsHistologic and fluorescent in situ hybridization (FISH) analysis of three separate skin biopsies, one of which was separated by 21 months from the others, were performed in a 71-year-old patient with BDUMP to assess for histologic and chromosomal abnormality. Conjunctival histologic evaluation was also done.ResultsDermal melanocytic proliferation was seen in each specimen. The cells were spindle type with mitotic activity. FISH analysis showed a normal copy of chromosomes. The conjunctival sample also showed normal FISH analysis.ConclusionBDUMP is associated with multifocal dermal and conjunctival melanocytic proliferation.

KW - Bilateral diffuse uveal melanocytic proliferation

KW - Cancer

KW - Dermal proliferation

KW - Melanoma

KW - Paraneoplastic syndromes

KW - Uveal melanoma

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Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation

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Keywords

ASJC Scopus subject areas

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