Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation

Jose S Pulido, Thomas J Flotte, H. Raja, S. Miles, J. L. Winters, R. Niles, E. A. Jaben, Svetomir Nenad Markovic, J. Davies, K. R. Kalli, Richard Geoffrey Vile, J. J. Garcia, D. R. Salomao

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

AimThe goal of this case report is to describe the dermatologic and conjunctival findings in a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), a paraneoplastic syndrome usually associated with gynecologic cancers. There is little information about other dermatologic melanocytic findings in these patients.MethodsHistologic and fluorescent in situ hybridization (FISH) analysis of three separate skin biopsies, one of which was separated by 21 months from the others, were performed in a 71-year-old patient with BDUMP to assess for histologic and chromosomal abnormality. Conjunctival histologic evaluation was also done.ResultsDermal melanocytic proliferation was seen in each specimen. The cells were spindle type with mitotic activity. FISH analysis showed a normal copy of chromosomes. The conjunctival sample also showed normal FISH analysis.ConclusionBDUMP is associated with multifocal dermal and conjunctival melanocytic proliferation.

Original languageEnglish (US)
Pages (from-to)1058-1062
Number of pages5
JournalEye (Basingstoke)
Volume27
Issue number9
DOIs
StatePublished - Sep 2013

Fingerprint

Fluorescence In Situ Hybridization
Skin
Paraneoplastic Syndromes
Spindle Apparatus
Chromosome Aberrations
Chromosomes
Biopsy
Neoplasms

Keywords

  • Bilateral diffuse uveal melanocytic proliferation
  • Cancer
  • Dermal proliferation
  • Melanoma
  • Paraneoplastic syndromes
  • Uveal melanoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation. / Pulido, Jose S; Flotte, Thomas J; Raja, H.; Miles, S.; Winters, J. L.; Niles, R.; Jaben, E. A.; Markovic, Svetomir Nenad; Davies, J.; Kalli, K. R.; Vile, Richard Geoffrey; Garcia, J. J.; Salomao, D. R.

In: Eye (Basingstoke), Vol. 27, No. 9, 09.2013, p. 1058-1062.

Research output: Contribution to journalArticle

Pulido, JS, Flotte, TJ, Raja, H, Miles, S, Winters, JL, Niles, R, Jaben, EA, Markovic, SN, Davies, J, Kalli, KR, Vile, RG, Garcia, JJ & Salomao, DR 2013, 'Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation', Eye (Basingstoke), vol. 27, no. 9, pp. 1058-1062. https://doi.org/10.1038/eye.2013.131
Pulido, Jose S ; Flotte, Thomas J ; Raja, H. ; Miles, S. ; Winters, J. L. ; Niles, R. ; Jaben, E. A. ; Markovic, Svetomir Nenad ; Davies, J. ; Kalli, K. R. ; Vile, Richard Geoffrey ; Garcia, J. J. ; Salomao, D. R. / Dermal and conjunctival melanocytic proliferations in diffuse uveal melanocytic proliferation. In: Eye (Basingstoke). 2013 ; Vol. 27, No. 9. pp. 1058-1062.
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AB - AimThe goal of this case report is to describe the dermatologic and conjunctival findings in a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), a paraneoplastic syndrome usually associated with gynecologic cancers. There is little information about other dermatologic melanocytic findings in these patients.MethodsHistologic and fluorescent in situ hybridization (FISH) analysis of three separate skin biopsies, one of which was separated by 21 months from the others, were performed in a 71-year-old patient with BDUMP to assess for histologic and chromosomal abnormality. Conjunctival histologic evaluation was also done.ResultsDermal melanocytic proliferation was seen in each specimen. The cells were spindle type with mitotic activity. FISH analysis showed a normal copy of chromosomes. The conjunctival sample also showed normal FISH analysis.ConclusionBDUMP is associated with multifocal dermal and conjunctival melanocytic proliferation.

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