Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the Mayo Clinic Study of Aging

Janina Krell-Roesch, Val Lowe, Jennifer Neureiter, Anna Pink, Rosebud O Roberts, Michelle M Mielke, Prashanthi D Vemuri, Gorazd B. Stokin, Teresa J. Christianson, Clifford R Jr. Jack, David S Knopman, Bradley F Boeve, Walter K Kremers, Ronald Carl Petersen, Yonas Endale Geda

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Abstract

Background:: Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. Methods:: We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota; involving CN persons aged ≥ 60 years that underwent PiB-PET scans and completed Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Cognitive diagnosis was made by an expert consensus panel. Participants were classified as having abnormal (≥1.4; PiB+) or normal PiB-PET (<1.4; PiB−) using a global cortical to cerebellar ratio. Multi-variable logistic regression analyses were performed to calculate odds ratios (OR) and 95% confidence intervals (95% CI) after adjusting for age and sex. Results:: Of 1,038 CN participants (53.1% males), 379 were PiB+. Each one point symptom increase in the BDI (OR = 1.03; 1.00–1.06) and BAI (OR = 1.04; 1.01–1.08) was associated with increased odds of PiB-PET+. The number of participants with BDI > 13 (clinical depression) was greater in the PiB-PET+ than PiB-PET- group but the difference was not significant (OR = 1.42; 0.83–2.43). Similarly, the number of participants with BAI > 10 (clinical anxiety) was greater in the PiB-PET+ than PiB-PET− group but the difference was not significant (OR = 1.77; 0.97–3.22). Conclusions:: As expected, depression and anxiety levels were low in this community-dwelling sample, which likely reduced our statistical power. However, we observed an informative albeit weak association between increased BDI and BAI scores and elevated cortical amyloid deposition. This observation needs to be tested in a longitudinal cohort study.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalInternational Psychogeriatrics
DOIs
StateAccepted/In press - Dec 4 2017

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Amyloid
Anxiety
Depression
Equipment and Supplies
Independent Living
Positron-Emission Tomography
Longitudinal Studies
Consensus
Cohort Studies
Cross-Sectional Studies
Population

Keywords

  • anxiety symptoms
  • cognitively normal persons
  • cortical amyloid deposition
  • depressive symptoms

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

@article{2ce504a29a194896afdddb79bf389328,
title = "Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the Mayo Clinic Study of Aging",
abstract = "Background:: Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. Methods:: We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota; involving CN persons aged ≥ 60 years that underwent PiB-PET scans and completed Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Cognitive diagnosis was made by an expert consensus panel. Participants were classified as having abnormal (≥1.4; PiB+) or normal PiB-PET (<1.4; PiB−) using a global cortical to cerebellar ratio. Multi-variable logistic regression analyses were performed to calculate odds ratios (OR) and 95{\%} confidence intervals (95{\%} CI) after adjusting for age and sex. Results:: Of 1,038 CN participants (53.1{\%} males), 379 were PiB+. Each one point symptom increase in the BDI (OR = 1.03; 1.00–1.06) and BAI (OR = 1.04; 1.01–1.08) was associated with increased odds of PiB-PET+. The number of participants with BDI > 13 (clinical depression) was greater in the PiB-PET+ than PiB-PET- group but the difference was not significant (OR = 1.42; 0.83–2.43). Similarly, the number of participants with BAI > 10 (clinical anxiety) was greater in the PiB-PET+ than PiB-PET− group but the difference was not significant (OR = 1.77; 0.97–3.22). Conclusions:: As expected, depression and anxiety levels were low in this community-dwelling sample, which likely reduced our statistical power. However, we observed an informative albeit weak association between increased BDI and BAI scores and elevated cortical amyloid deposition. This observation needs to be tested in a longitudinal cohort study.",
keywords = "anxiety symptoms, cognitively normal persons, cortical amyloid deposition, depressive symptoms",
author = "Janina Krell-Roesch and Val Lowe and Jennifer Neureiter and Anna Pink and Roberts, {Rosebud O} and Mielke, {Michelle M} and Vemuri, {Prashanthi D} and Stokin, {Gorazd B.} and Christianson, {Teresa J.} and Jack, {Clifford R Jr.} and Knopman, {David S} and Boeve, {Bradley F} and Kremers, {Walter K} and Petersen, {Ronald Carl} and Geda, {Yonas Endale}",
year = "2017",
month = "12",
day = "4",
doi = "10.1017/S1041610217002368",
language = "English (US)",
pages = "1--7",
journal = "International psychogeriatrics / IPA",
issn = "1041-6102",
publisher = "Cambridge University Press",

}

TY - JOUR

T1 - Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons

T2 - the Mayo Clinic Study of Aging

AU - Krell-Roesch, Janina

AU - Lowe, Val

AU - Neureiter, Jennifer

AU - Pink, Anna

AU - Roberts, Rosebud O

AU - Mielke, Michelle M

AU - Vemuri, Prashanthi D

AU - Stokin, Gorazd B.

AU - Christianson, Teresa J.

AU - Jack, Clifford R Jr.

AU - Knopman, David S

AU - Boeve, Bradley F

AU - Kremers, Walter K

AU - Petersen, Ronald Carl

AU - Geda, Yonas Endale

PY - 2017/12/4

Y1 - 2017/12/4

N2 - Background:: Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. Methods:: We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota; involving CN persons aged ≥ 60 years that underwent PiB-PET scans and completed Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Cognitive diagnosis was made by an expert consensus panel. Participants were classified as having abnormal (≥1.4; PiB+) or normal PiB-PET (<1.4; PiB−) using a global cortical to cerebellar ratio. Multi-variable logistic regression analyses were performed to calculate odds ratios (OR) and 95% confidence intervals (95% CI) after adjusting for age and sex. Results:: Of 1,038 CN participants (53.1% males), 379 were PiB+. Each one point symptom increase in the BDI (OR = 1.03; 1.00–1.06) and BAI (OR = 1.04; 1.01–1.08) was associated with increased odds of PiB-PET+. The number of participants with BDI > 13 (clinical depression) was greater in the PiB-PET+ than PiB-PET- group but the difference was not significant (OR = 1.42; 0.83–2.43). Similarly, the number of participants with BAI > 10 (clinical anxiety) was greater in the PiB-PET+ than PiB-PET− group but the difference was not significant (OR = 1.77; 0.97–3.22). Conclusions:: As expected, depression and anxiety levels were low in this community-dwelling sample, which likely reduced our statistical power. However, we observed an informative albeit weak association between increased BDI and BAI scores and elevated cortical amyloid deposition. This observation needs to be tested in a longitudinal cohort study.

AB - Background:: Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. Methods:: We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota; involving CN persons aged ≥ 60 years that underwent PiB-PET scans and completed Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Cognitive diagnosis was made by an expert consensus panel. Participants were classified as having abnormal (≥1.4; PiB+) or normal PiB-PET (<1.4; PiB−) using a global cortical to cerebellar ratio. Multi-variable logistic regression analyses were performed to calculate odds ratios (OR) and 95% confidence intervals (95% CI) after adjusting for age and sex. Results:: Of 1,038 CN participants (53.1% males), 379 were PiB+. Each one point symptom increase in the BDI (OR = 1.03; 1.00–1.06) and BAI (OR = 1.04; 1.01–1.08) was associated with increased odds of PiB-PET+. The number of participants with BDI > 13 (clinical depression) was greater in the PiB-PET+ than PiB-PET- group but the difference was not significant (OR = 1.42; 0.83–2.43). Similarly, the number of participants with BAI > 10 (clinical anxiety) was greater in the PiB-PET+ than PiB-PET− group but the difference was not significant (OR = 1.77; 0.97–3.22). Conclusions:: As expected, depression and anxiety levels were low in this community-dwelling sample, which likely reduced our statistical power. However, we observed an informative albeit weak association between increased BDI and BAI scores and elevated cortical amyloid deposition. This observation needs to be tested in a longitudinal cohort study.

KW - anxiety symptoms

KW - cognitively normal persons

KW - cortical amyloid deposition

KW - depressive symptoms

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