Abstract
Background:: Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. Methods:: We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota; involving CN persons aged ≥ 60 years that underwent PiB-PET scans and completed Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Cognitive diagnosis was made by an expert consensus panel. Participants were classified as having abnormal (≥1.4; PiB+) or normal PiB-PET (<1.4; PiB−) using a global cortical to cerebellar ratio. Multi-variable logistic regression analyses were performed to calculate odds ratios (OR) and 95% confidence intervals (95% CI) after adjusting for age and sex. Results:: Of 1,038 CN participants (53.1% males), 379 were PiB+. Each one point symptom increase in the BDI (OR = 1.03; 1.00–1.06) and BAI (OR = 1.04; 1.01–1.08) was associated with increased odds of PiB-PET+. The number of participants with BDI > 13 (clinical depression) was greater in the PiB-PET+ than PiB-PET- group but the difference was not significant (OR = 1.42; 0.83–2.43). Similarly, the number of participants with BAI > 10 (clinical anxiety) was greater in the PiB-PET+ than PiB-PET− group but the difference was not significant (OR = 1.77; 0.97–3.22). Conclusions:: As expected, depression and anxiety levels were low in this community-dwelling sample, which likely reduced our statistical power. However, we observed an informative albeit weak association between increased BDI and BAI scores and elevated cortical amyloid deposition. This observation needs to be tested in a longitudinal cohort study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | International Psychogeriatrics |
| DOIs | |
| State | Accepted/In press - Dec 4 2017 |
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Keywords
- anxiety symptoms
- cognitively normal persons
- cortical amyloid deposition
- depressive symptoms
ASJC Scopus subject areas
- Clinical Psychology
- Gerontology
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons : the Mayo Clinic Study of Aging. / Krell-Roesch, Janina; Lowe, Val; Neureiter, Jennifer; Pink, Anna; Roberts, Rosebud O; Mielke, Michelle M; Vemuri, Prashanthi D; Stokin, Gorazd B.; Christianson, Teresa J.; Jack, Clifford R Jr.; Knopman, David S; Boeve, Bradley F; Kremers, Walter K; Petersen, Ronald Carl; Geda, Yonas Endale.
In: International Psychogeriatrics, 04.12.2017, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons
T2 - the Mayo Clinic Study of Aging
AU - Krell-Roesch, Janina
AU - Lowe, Val
AU - Neureiter, Jennifer
AU - Pink, Anna
AU - Roberts, Rosebud O
AU - Mielke, Michelle M
AU - Vemuri, Prashanthi D
AU - Stokin, Gorazd B.
AU - Christianson, Teresa J.
AU - Jack, Clifford R Jr.
AU - Knopman, David S
AU - Boeve, Bradley F
AU - Kremers, Walter K
AU - Petersen, Ronald Carl
AU - Geda, Yonas Endale
PY - 2017/12/4
Y1 - 2017/12/4
N2 - Background:: Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. Methods:: We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota; involving CN persons aged ≥ 60 years that underwent PiB-PET scans and completed Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Cognitive diagnosis was made by an expert consensus panel. Participants were classified as having abnormal (≥1.4; PiB+) or normal PiB-PET (<1.4; PiB−) using a global cortical to cerebellar ratio. Multi-variable logistic regression analyses were performed to calculate odds ratios (OR) and 95% confidence intervals (95% CI) after adjusting for age and sex. Results:: Of 1,038 CN participants (53.1% males), 379 were PiB+. Each one point symptom increase in the BDI (OR = 1.03; 1.00–1.06) and BAI (OR = 1.04; 1.01–1.08) was associated with increased odds of PiB-PET+. The number of participants with BDI > 13 (clinical depression) was greater in the PiB-PET+ than PiB-PET- group but the difference was not significant (OR = 1.42; 0.83–2.43). Similarly, the number of participants with BAI > 10 (clinical anxiety) was greater in the PiB-PET+ than PiB-PET− group but the difference was not significant (OR = 1.77; 0.97–3.22). Conclusions:: As expected, depression and anxiety levels were low in this community-dwelling sample, which likely reduced our statistical power. However, we observed an informative albeit weak association between increased BDI and BAI scores and elevated cortical amyloid deposition. This observation needs to be tested in a longitudinal cohort study.
AB - Background:: Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. Methods:: We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota; involving CN persons aged ≥ 60 years that underwent PiB-PET scans and completed Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Cognitive diagnosis was made by an expert consensus panel. Participants were classified as having abnormal (≥1.4; PiB+) or normal PiB-PET (<1.4; PiB−) using a global cortical to cerebellar ratio. Multi-variable logistic regression analyses were performed to calculate odds ratios (OR) and 95% confidence intervals (95% CI) after adjusting for age and sex. Results:: Of 1,038 CN participants (53.1% males), 379 were PiB+. Each one point symptom increase in the BDI (OR = 1.03; 1.00–1.06) and BAI (OR = 1.04; 1.01–1.08) was associated with increased odds of PiB-PET+. The number of participants with BDI > 13 (clinical depression) was greater in the PiB-PET+ than PiB-PET- group but the difference was not significant (OR = 1.42; 0.83–2.43). Similarly, the number of participants with BAI > 10 (clinical anxiety) was greater in the PiB-PET+ than PiB-PET− group but the difference was not significant (OR = 1.77; 0.97–3.22). Conclusions:: As expected, depression and anxiety levels were low in this community-dwelling sample, which likely reduced our statistical power. However, we observed an informative albeit weak association between increased BDI and BAI scores and elevated cortical amyloid deposition. This observation needs to be tested in a longitudinal cohort study.
KW - anxiety symptoms
KW - cognitively normal persons
KW - cortical amyloid deposition
KW - depressive symptoms
UR - http://www.scopus.com/inward/record.url?scp=85037988513&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85037988513&partnerID=8YFLogxK
U2 - 10.1017/S1041610217002368
DO - 10.1017/S1041610217002368
M3 - Article
C2 - 29198244
AN - SCOPUS:85037988513
SP - 1
EP - 7
JO - International psychogeriatrics / IPA
JF - International psychogeriatrics / IPA
SN - 1041-6102
ER -