TY - JOUR
T1 - Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies
AU - López De Padilla, Consuelo M.
AU - Reed, Ann M.
PY - 2008/11
Y1 - 2008/11
N2 - Purpose of review: Mechanisms driving the autoimmune process in idiopathic inflammatory myopathies (IIMs) have not been unraveled, despite extensive studies. In recent times, it has become apparent that heterogeneous populations of dendritic cells have specialized roles in IIM. Here, we will discuss the role of dendritic cells in the induction of adaptive immune response in HM and review the recent literature addressing the role of dendritic cells in the cause and pathogenesis of inflammatory myopathies. Recent findings: Different subsets of immature and mature dendritic cells have been recently identified in skeletal muscle in IIM. Dendritic cells present in inclusion body myositis and polymyositis are primarily myeloid dendritic cells. In contrast, plasmacytoid dendritic cells, a subset of dendritic cells and considered the main source of the interferon-α/β (IFN-α/β), have been found abundantly in muscle tissue of adult dermatomyositis and juvenile dermatomyositis. Summary: Dendritic cells are associated with the chronic infiltration of mononuclear cells in the inflammatory muscle tissue of HM patients. Increasing evidences point out that dendritic cells are not only crucially involved in the initiation of anti-self immune response but are also essential for the maintenance of autoimmune lesions in inflammatory myopathies.
AB - Purpose of review: Mechanisms driving the autoimmune process in idiopathic inflammatory myopathies (IIMs) have not been unraveled, despite extensive studies. In recent times, it has become apparent that heterogeneous populations of dendritic cells have specialized roles in IIM. Here, we will discuss the role of dendritic cells in the induction of adaptive immune response in HM and review the recent literature addressing the role of dendritic cells in the cause and pathogenesis of inflammatory myopathies. Recent findings: Different subsets of immature and mature dendritic cells have been recently identified in skeletal muscle in IIM. Dendritic cells present in inclusion body myositis and polymyositis are primarily myeloid dendritic cells. In contrast, plasmacytoid dendritic cells, a subset of dendritic cells and considered the main source of the interferon-α/β (IFN-α/β), have been found abundantly in muscle tissue of adult dermatomyositis and juvenile dermatomyositis. Summary: Dendritic cells are associated with the chronic infiltration of mononuclear cells in the inflammatory muscle tissue of HM patients. Increasing evidences point out that dendritic cells are not only crucially involved in the initiation of anti-self immune response but are also essential for the maintenance of autoimmune lesions in inflammatory myopathies.
KW - Dendritic cells
KW - Idiopathic inflammatory myopathies
KW - Myeloid dendritic cells
KW - Plasmacytoid dendritic cells
KW - Type I interferons
UR - http://www.scopus.com/inward/record.url?scp=56249101376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56249101376&partnerID=8YFLogxK
U2 - 10.1097/BOR.0b013e3283157538
DO - 10.1097/BOR.0b013e3283157538
M3 - Review article
C2 - 18946326
AN - SCOPUS:56249101376
SN - 1040-8711
VL - 20
SP - 669
EP - 674
JO - Current opinion in rheumatology
JF - Current opinion in rheumatology
IS - 6
ER -