Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies

Consuelo M. López De Padilla, Ann M. Reed

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose of review: Mechanisms driving the autoimmune process in idiopathic inflammatory myopathies (IIMs) have not been unraveled, despite extensive studies. In recent times, it has become apparent that heterogeneous populations of dendritic cells have specialized roles in IIM. Here, we will discuss the role of dendritic cells in the induction of adaptive immune response in HM and review the recent literature addressing the role of dendritic cells in the cause and pathogenesis of inflammatory myopathies. Recent findings: Different subsets of immature and mature dendritic cells have been recently identified in skeletal muscle in IIM. Dendritic cells present in inclusion body myositis and polymyositis are primarily myeloid dendritic cells. In contrast, plasmacytoid dendritic cells, a subset of dendritic cells and considered the main source of the interferon-α/β (IFN-α/β), have been found abundantly in muscle tissue of adult dermatomyositis and juvenile dermatomyositis. Summary: Dendritic cells are associated with the chronic infiltration of mononuclear cells in the inflammatory muscle tissue of HM patients. Increasing evidences point out that dendritic cells are not only crucially involved in the initiation of anti-self immune response but are also essential for the maintenance of autoimmune lesions in inflammatory myopathies.

Original languageEnglish (US)
Pages (from-to)669-674
Number of pages6
JournalCurrent Opinion in Rheumatology
Volume20
Issue number6
DOIs
StatePublished - Nov 2008

Fingerprint

Myositis
Dendritic Cells
Inclusion Body Myositis
Polymyositis
Muscles
Dermatomyositis
Adaptive Immunity
Myeloid Cells
Interferons
Skeletal Muscle
Maintenance

Keywords

  • Dendritic cells
  • Idiopathic inflammatory myopathies
  • Myeloid dendritic cells
  • Plasmacytoid dendritic cells
  • Type I interferons

ASJC Scopus subject areas

  • Rheumatology

Cite this

Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies. / López De Padilla, Consuelo M.; Reed, Ann M.

In: Current Opinion in Rheumatology, Vol. 20, No. 6, 11.2008, p. 669-674.

Research output: Contribution to journalArticle

López De Padilla, Consuelo M. ; Reed, Ann M. / Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies. In: Current Opinion in Rheumatology. 2008 ; Vol. 20, No. 6. pp. 669-674.
@article{06a95ce0dfd149a1a222d027eee41d83,
title = "Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies",
abstract = "Purpose of review: Mechanisms driving the autoimmune process in idiopathic inflammatory myopathies (IIMs) have not been unraveled, despite extensive studies. In recent times, it has become apparent that heterogeneous populations of dendritic cells have specialized roles in IIM. Here, we will discuss the role of dendritic cells in the induction of adaptive immune response in HM and review the recent literature addressing the role of dendritic cells in the cause and pathogenesis of inflammatory myopathies. Recent findings: Different subsets of immature and mature dendritic cells have been recently identified in skeletal muscle in IIM. Dendritic cells present in inclusion body myositis and polymyositis are primarily myeloid dendritic cells. In contrast, plasmacytoid dendritic cells, a subset of dendritic cells and considered the main source of the interferon-α/β (IFN-α/β), have been found abundantly in muscle tissue of adult dermatomyositis and juvenile dermatomyositis. Summary: Dendritic cells are associated with the chronic infiltration of mononuclear cells in the inflammatory muscle tissue of HM patients. Increasing evidences point out that dendritic cells are not only crucially involved in the initiation of anti-self immune response but are also essential for the maintenance of autoimmune lesions in inflammatory myopathies.",
keywords = "Dendritic cells, Idiopathic inflammatory myopathies, Myeloid dendritic cells, Plasmacytoid dendritic cells, Type I interferons",
author = "{L{\'o}pez De Padilla}, {Consuelo M.} and Reed, {Ann M.}",
year = "2008",
month = "11",
doi = "10.1097/BOR.0b013e3283157538",
language = "English (US)",
volume = "20",
pages = "669--674",
journal = "Current Opinion in Rheumatology",
issn = "1040-8711",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies

AU - López De Padilla, Consuelo M.

AU - Reed, Ann M.

PY - 2008/11

Y1 - 2008/11

N2 - Purpose of review: Mechanisms driving the autoimmune process in idiopathic inflammatory myopathies (IIMs) have not been unraveled, despite extensive studies. In recent times, it has become apparent that heterogeneous populations of dendritic cells have specialized roles in IIM. Here, we will discuss the role of dendritic cells in the induction of adaptive immune response in HM and review the recent literature addressing the role of dendritic cells in the cause and pathogenesis of inflammatory myopathies. Recent findings: Different subsets of immature and mature dendritic cells have been recently identified in skeletal muscle in IIM. Dendritic cells present in inclusion body myositis and polymyositis are primarily myeloid dendritic cells. In contrast, plasmacytoid dendritic cells, a subset of dendritic cells and considered the main source of the interferon-α/β (IFN-α/β), have been found abundantly in muscle tissue of adult dermatomyositis and juvenile dermatomyositis. Summary: Dendritic cells are associated with the chronic infiltration of mononuclear cells in the inflammatory muscle tissue of HM patients. Increasing evidences point out that dendritic cells are not only crucially involved in the initiation of anti-self immune response but are also essential for the maintenance of autoimmune lesions in inflammatory myopathies.

AB - Purpose of review: Mechanisms driving the autoimmune process in idiopathic inflammatory myopathies (IIMs) have not been unraveled, despite extensive studies. In recent times, it has become apparent that heterogeneous populations of dendritic cells have specialized roles in IIM. Here, we will discuss the role of dendritic cells in the induction of adaptive immune response in HM and review the recent literature addressing the role of dendritic cells in the cause and pathogenesis of inflammatory myopathies. Recent findings: Different subsets of immature and mature dendritic cells have been recently identified in skeletal muscle in IIM. Dendritic cells present in inclusion body myositis and polymyositis are primarily myeloid dendritic cells. In contrast, plasmacytoid dendritic cells, a subset of dendritic cells and considered the main source of the interferon-α/β (IFN-α/β), have been found abundantly in muscle tissue of adult dermatomyositis and juvenile dermatomyositis. Summary: Dendritic cells are associated with the chronic infiltration of mononuclear cells in the inflammatory muscle tissue of HM patients. Increasing evidences point out that dendritic cells are not only crucially involved in the initiation of anti-self immune response but are also essential for the maintenance of autoimmune lesions in inflammatory myopathies.

KW - Dendritic cells

KW - Idiopathic inflammatory myopathies

KW - Myeloid dendritic cells

KW - Plasmacytoid dendritic cells

KW - Type I interferons

UR - http://www.scopus.com/inward/record.url?scp=56249101376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56249101376&partnerID=8YFLogxK

U2 - 10.1097/BOR.0b013e3283157538

DO - 10.1097/BOR.0b013e3283157538

M3 - Article

VL - 20

SP - 669

EP - 674

JO - Current Opinion in Rheumatology

JF - Current Opinion in Rheumatology

SN - 1040-8711

IS - 6

ER -