Demonstration of intrathecal and systemic morphine and ST-91 effects on fed canine upper gut motility

G. M. Thomforde, J. R. Malagelada, M. Camilleri, T. L. Yaksh

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We studied the effects of opioid and adrenergic agonists and antagonists given systemically intravenously and intrathecally on postprandial antral and small bowel motility in a chronic conscious dog model. We studied eight dogs with a surgically implanted thoracic spinal intrathecal injection catheter, and six gastrointestinal manometric perfusion catheters. Morphine given intrathecally or intravenously induced propagated clusters of intestinal pressure activity in the fed dogs. The minimal effective dose for morphine was 150 μg/kg by the intrathecal route and 450 μg/kg by the intravenous route. ST-91 (an α2-adrenergic agonist) profoundly inhibited antral and small intestinal pressure activity with similar minimal effective dose (100 μg/kg) and duration of effect for both intravenous and intrathecal routes. Neither naloxone (3000 μg/kg) nor combined phentolamine (1500 μg/kg) with propranolol (300 μg/kg) altered postprandial antral or small intestinal motility. The capacity of pharmacologic agents to block morphine-induced activity fronts when administered in the same compartment (intravenously or intrathecally) was investigated. The minimally effective morphine-antagonist dose for naloxone was similar intrathecally and intravenously (36 μg/kg for both routes). ST-91 (100 μg/kg) when given intrathecally or intravenously blocked morphine-induced clustered phasic pressure activity while simultaneously abolishing postprandial small intestine phasic pressure activity. These data suggest the presence of opioid and α2-adrenergic receptors in the spinal cord that can modulate gastrointestinal motility in the postprandial state. Pharmacological interactions between these systems occur at spinal and target organ levels.

Original languageEnglish (US)
Pages (from-to)1249-1256
Number of pages8
JournalDigestive diseases and sciences
Volume35
Issue number10
DOIs
StatePublished - Oct 1 1990

Keywords

  • adrenergic agonists
  • gastrointestinal motility
  • opiates
  • spinal receptors

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Demonstration of intrathecal and systemic morphine and ST-91 effects on fed canine upper gut motility'. Together they form a unique fingerprint.

  • Cite this