Dementia following herpes zoster encephalitis

Katherine J. Bangen, Lisa Delano-Wood, Christina E. Wierenga, Nikki H. Stricker, John R. Hesselink, Mark W. Bondi

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We studied the rare case of an older adult with dementia following herpes zoster encephalitis (HZE). This 71-year-old woman presented to us approximately 1 year following resolution of a rapid-onset episode of HZE, and subsequently underwent neuropsychological and neuroimaging examinations. Cognitive assessment revealed impairments in general cognitive functioning, verbal and nonverbal memory, executive functions, speed of information processing, attention/working memory, and motor skills. The patient's neuroimaging data, when compared to a demographically similar healthy control sample (n = 9), demonstrated moderate central and perisylvian brain volume loss, several subcortical lesions in the white matter, and resting state whole brain and hippocampal hypoperfusion. These findings highlight neuropsychological changes evident in a dementia syndrome of this type, and they suggest that early identification and treatment of HZE has implications for the preservation of long-term cognitive functioning.

Original languageEnglish (US)
Pages (from-to)1193-1203
Number of pages11
JournalClinical Neuropsychologist
Volume24
Issue number7
DOIs
StatePublished - Oct 2010

Keywords

  • Cognition
  • Dementia
  • Encephalitis
  • Herpes zoster
  • MRI

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology
  • Clinical Psychology
  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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    Bangen, K. J., Delano-Wood, L., Wierenga, C. E., Stricker, N. H., Hesselink, J. R., & Bondi, M. W. (2010). Dementia following herpes zoster encephalitis. Clinical Neuropsychologist, 24(7), 1193-1203. https://doi.org/10.1080/13854041003736778