Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia

Cheryl L. Willman, Cordelia E. Sever, Maria G. Pallavicini, Hisashi Harada, Nobuyuki Tanaka, Marilyn L. Slovak, Hitomi Yamamoto, Kenji Harada, Timothy C. Meeker, Alan F. List, Tadatsugu Taniguchi

Research output: Contribution to journalArticlepeer-review

Abstract

One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1, a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromericto IL-3 and GM-CSF. Among these genes, only IRF-1 was consistently deleted at one or both alleles in 13 cases of leukemia or myelodysplasia with aberrations of 5q31. Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia.

Original languageEnglish (US)
Pages (from-to)968-971
Number of pages4
JournalScience
Volume259
Issue number5097
DOIs
StatePublished - 1993

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