Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia

Cheryl L. Willman; Cordelia E. Sever; Maria G. Pallavicini; Hisashi Harada; Nobuyuki Tanaka; Marilyn L. Slovak; Hitomi Yamamoto; Kenji Harada; Timothy C. Meeker; Alan F. List; Tadatsugu Taniguchi

doi:10.1126/science.8438156

Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia

Cheryl L. Willman, Cordelia E. Sever, Maria G. Pallavicini, Hisashi Harada, Nobuyuki Tanaka, Marilyn L. Slovak, Hitomi Yamamoto, Kenji Harada, Timothy C. Meeker, Alan F. List, Tadatsugu Taniguchi

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1, a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromericto IL-3 and GM-CSF. Among these genes, only IRF-1 was consistently deleted at one or both alleles in 13 cases of leukemia or myelodysplasia with aberrations of 5q31. Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia.

Original language	English (US)
Pages (from-to)	968-971
Number of pages	4
Journal	Science
Volume	259
Issue number	5097
DOIs	https://doi.org/10.1126/science.8438156
State	Published - 1993

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@article{e5a0cec249394668939f9ee417b8f1b4,

title = "Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia",

abstract = "One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1, a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromericto IL-3 and GM-CSF. Among these genes, only IRF-1 was consistently deleted at one or both alleles in 13 cases of leukemia or myelodysplasia with aberrations of 5q31. Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia.",

author = "Willman, {Cheryl L.} and Sever, {Cordelia E.} and Pallavicini, {Maria G.} and Hisashi Harada and Nobuyuki Tanaka and Slovak, {Marilyn L.} and Hitomi Yamamoto and Kenji Harada and Meeker, {Timothy C.} and List, {Alan F.} and Tadatsugu Taniguchi",

year = "1993",

doi = "10.1126/science.8438156",

language = "English (US)",

volume = "259",

pages = "968--971",

journal = "Science",

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T1 - Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia

AU - Willman, Cheryl L.

AU - Sever, Cordelia E.

AU - Pallavicini, Maria G.

AU - Harada, Hisashi

AU - Tanaka, Nobuyuki

AU - Slovak, Marilyn L.

AU - Yamamoto, Hitomi

AU - Harada, Kenji

AU - Meeker, Timothy C.

AU - List, Alan F.

AU - Taniguchi, Tadatsugu

PY - 1993

Y1 - 1993

N2 - One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1, a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromericto IL-3 and GM-CSF. Among these genes, only IRF-1 was consistently deleted at one or both alleles in 13 cases of leukemia or myelodysplasia with aberrations of 5q31. Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia.

AB - One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1, a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromericto IL-3 and GM-CSF. Among these genes, only IRF-1 was consistently deleted at one or both alleles in 13 cases of leukemia or myelodysplasia with aberrations of 5q31. Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia.

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ER -

Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia

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