Defective lymphoid development in mice lacking Jak3

Tetsuya Nosaka, Jan Van Deursen, Ralph A. Tripp, William E. Thierfelder, Bruce A. Witthuhn, Anthony P. McMickle, Peter C. Doherty, Gerard C. Grosveld, James N. Ihle

Research output: Contribution to journalArticle

518 Citations (Scopus)

Abstract

The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors. Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is predominantly expressed in hematopoietic cells and is known to associate only with the common γ (γc) chain of the interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 receptors. Homozygous mutant mice in which the Jak3 gene had been disrupted were generated by gene targeting. Jak3-deficient mice had profound reductions in thymocytes and severe B cell and T cell lymphopenia similar to severe combined immunodeficiency disease (SCID), and the residual T cells and B cells were functionally deficient. Thus, Jak3 plays a critical role in γc signaling and lymphoid development.

Original languageEnglish (US)
Pages (from-to)800-802
Number of pages3
JournalScience
Volume270
Issue number5237
StatePublished - 1995
Externally publishedYes

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Interleukin-15 Receptors
B-Lymphocytes
Interleukin-9
Janus Kinases
T-Lymphocytes
Severe Combined Immunodeficiency
Interleukin-7
Lymphopenia
Cytokine Receptors
Gene Targeting
Thymocytes
Interleukin-4
Protein-Tyrosine Kinases
Interleukin-2
Genes

ASJC Scopus subject areas

  • General

Cite this

Nosaka, T., Van Deursen, J., Tripp, R. A., Thierfelder, W. E., Witthuhn, B. A., McMickle, A. P., ... Ihle, J. N. (1995). Defective lymphoid development in mice lacking Jak3. Science, 270(5237), 800-802.

Defective lymphoid development in mice lacking Jak3. / Nosaka, Tetsuya; Van Deursen, Jan; Tripp, Ralph A.; Thierfelder, William E.; Witthuhn, Bruce A.; McMickle, Anthony P.; Doherty, Peter C.; Grosveld, Gerard C.; Ihle, James N.

In: Science, Vol. 270, No. 5237, 1995, p. 800-802.

Research output: Contribution to journalArticle

Nosaka, T, Van Deursen, J, Tripp, RA, Thierfelder, WE, Witthuhn, BA, McMickle, AP, Doherty, PC, Grosveld, GC & Ihle, JN 1995, 'Defective lymphoid development in mice lacking Jak3', Science, vol. 270, no. 5237, pp. 800-802.
Nosaka T, Van Deursen J, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP et al. Defective lymphoid development in mice lacking Jak3. Science. 1995;270(5237):800-802.
Nosaka, Tetsuya ; Van Deursen, Jan ; Tripp, Ralph A. ; Thierfelder, William E. ; Witthuhn, Bruce A. ; McMickle, Anthony P. ; Doherty, Peter C. ; Grosveld, Gerard C. ; Ihle, James N. / Defective lymphoid development in mice lacking Jak3. In: Science. 1995 ; Vol. 270, No. 5237. pp. 800-802.
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