Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis

Y. Zhang; R. K. Zabad; X. Wei; L. M. Metz; M. D. Hill; J. Ross Mitchell

doi:10.1177/1352458507076411

Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis

Y. Zhang, R. K. Zabad, X. Wei, L. M. Metz, M. D. Hill, J. Ross Mitchell

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43 Scopus citations

Abstract

T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = -0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study.

Original language	English (US)
Pages (from-to)	880-883
Number of pages	4
Journal	Multiple Sclerosis
Volume	13
Issue number	7
DOIs	https://doi.org/10.1177/1352458507076411
State	Published - Aug 2007

Keywords

Black T2
Deep grey matter
Disability
High field MRI
Iron deposition
Multiple sclerosis

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1177/1352458507076411

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title = "Deep grey matter {"}black T2{"} on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis",

abstract = "T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = -0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study.",

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T1 - Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis

AU - Zhang, Y.

AU - Zabad, R. K.

AU - Wei, X.

AU - Metz, L. M.

AU - Hill, M. D.

AU - Mitchell, J. Ross

PY - 2007/8

Y1 - 2007/8

N2 - T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = -0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study.

AB - T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = -0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study.

KW - Black T2

KW - Deep grey matter

KW - Disability

KW - High field MRI

KW - Iron deposition

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Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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