Deep brain stimulation of the internal segment of the globus pallidus in delayed runaway dyskinesia

John Graff-Radford, Kelly D. Foote, Ramon L. Rodriguez, Hubert H. Fernandez, Robert A. Hauser, Atchar Sudhyadhom, Christian A. Rosado, Justin C. Sanchez, Michael S. Okun

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Background: Dyskinesias that occur during a period without medication after embryonic cell transplantation have been commonly reported in double-blind trials; however, to date, they have not been reported in the few patients who participated in open-label pilot studies. Design: Single case observation with preoperative and postoperative data, and intraoperative single-cell physiology. Patient: A patient who underwent embryonic cell transplantation in 1993 as part of the University of South Florida open-label study was referred for evaluation of intractable dyskinesia of the right arm. The dyskinesia was present during evaluation of the patient after a 12-hour period without medication and was clinically disabling. It was manifested as a severe groping movement of the hand. Intraoperative physiologic evaluation revealed decreased firing rates in the internal segment of the globus pallidus. Results: Deep brain stimulation of the internal segment of the globus pallidus resulted in resolution of the dyskinesia. Conclusion: This case highlights the delayed development of runaway dyskinesia after a period without medication as an important potential long-term adverse effect of embryonic cell transplantation in patients with Parkinson disease.

Original languageEnglish (US)
Pages (from-to)1181-1184
Number of pages4
JournalArchives of neurology
Volume63
Issue number8
DOIs
StatePublished - Aug 1 2006

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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    Graff-Radford, J., Foote, K. D., Rodriguez, R. L., Fernandez, H. H., Hauser, R. A., Sudhyadhom, A., Rosado, C. A., Sanchez, J. C., & Okun, M. S. (2006). Deep brain stimulation of the internal segment of the globus pallidus in delayed runaway dyskinesia. Archives of neurology, 63(8), 1181-1184. https://doi.org/10.1001/archneur.63.8.1181