Deep brain stimulation for intractable chronic cluster headache

Proposals for patient selection

Massimo Leone, A. May, A. Franzini, G. Broggi, David William Dodick, A. Rapoport, P. J. Goadsby, J. Schoenen, V. Bonavita, G. Bussone

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Cluster headache is the most severe of the primary headaches. Positron emission tomography and functional MRI studies have shown that the ipsilateral posterior hypothalamus is activated during cluster headache attacks and is structurally asymmetric in these patients. These changes are highly specific for the condition and suggest that the cluster headache generator may be located in that brain area; they further suggest that electrical stimulation of that region might produce clinical improvement in chronic cluster headache sufferers refractory to medical therapy. In five patients with severe intractable chronic cluster headache, hypothalamic electrical stimulation produced complete and long-term pain relief with no relevant side-effects. We therefore consider it essential to propose criteria for selecting chronic cluster headache patients for hypothalamic deep brain stimulation before this procedure is undertaken at other academic medical centres.

Original languageEnglish (US)
Pages (from-to)934-937
Number of pages4
JournalCephalalgia
Volume24
Issue number11
DOIs
StatePublished - Nov 2004

Fingerprint

Cluster Headache
Deep Brain Stimulation
Patient Selection
Electric Stimulation
Posterior Hypothalamus
Positron-Emission Tomography
Headache
Magnetic Resonance Imaging
Pain
Brain

Keywords

  • Cluster headache
  • Deep brain stimulation
  • Hypothalamus
  • Surgery
  • Therapy

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Deep brain stimulation for intractable chronic cluster headache : Proposals for patient selection. / Leone, Massimo; May, A.; Franzini, A.; Broggi, G.; Dodick, David William; Rapoport, A.; Goadsby, P. J.; Schoenen, J.; Bonavita, V.; Bussone, G.

In: Cephalalgia, Vol. 24, No. 11, 11.2004, p. 934-937.

Research output: Contribution to journalArticle

Leone, M, May, A, Franzini, A, Broggi, G, Dodick, DW, Rapoport, A, Goadsby, PJ, Schoenen, J, Bonavita, V & Bussone, G 2004, 'Deep brain stimulation for intractable chronic cluster headache: Proposals for patient selection', Cephalalgia, vol. 24, no. 11, pp. 934-937. https://doi.org/10.1111/j.1468-2982.2004.00742.x
Leone, Massimo ; May, A. ; Franzini, A. ; Broggi, G. ; Dodick, David William ; Rapoport, A. ; Goadsby, P. J. ; Schoenen, J. ; Bonavita, V. ; Bussone, G. / Deep brain stimulation for intractable chronic cluster headache : Proposals for patient selection. In: Cephalalgia. 2004 ; Vol. 24, No. 11. pp. 934-937.
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