Decreased Catecholamines in the Adrenal Medulla of Patients with Parkinsonism

Stephen W. Carmiohael; Robert J. Wilson; W. Stephen Brimijoin; L. Joseph Melton; Haruo Okazaki; Tony L. Yaksh; J. Eric Ahlskog; Susan L. Stoddard; Gertrude M. Tyce

doi:10.1056/NEJM198801283180415

Decreased Catecholamines in the Adrenal Medulla of Patients with Parkinsonism

Stephen W. Carmiohael, Robert J. Wilson, W. Stephen Brimijoin, L. Joseph Melton, Haruo Okazaki, Tony L. Yaksh, J. Eric Ahlskog, Susan L. Stoddard, Gertrude M. Tyce

Research output: Contribution to journal › Letter › peer-review

37 Scopus citations

Abstract

To the Editor: Autologous transplantation of the adrenal medulla into the caudate nucleus has been used as a treatment for Parkinson's disease. The rationale for this approach is that the production of catecholamines by the chromaffin cells may restore the dopamine lost at the terminals of degenerated nigrostriatal neurons.¹ This has been shown to be a promising therapy in selected patients.² However, an earlier report of a study involving two older patients did not show promise.¹ It is possible that the unknown factor or factors causing Parkinson's disease or the extended drug therapy for this syndrome have a debilitating effect.

Original language	English (US)
Pages (from-to)	254
Number of pages	1
Journal	New England Journal of Medicine
Volume	318
Issue number	4
DOIs	https://doi.org/10.1056/NEJM198801283180415
State	Published - Jan 28 1988

ASJC Scopus subject areas

General Medicine

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title = "Decreased Catecholamines in the Adrenal Medulla of Patients with Parkinsonism",

abstract = "To the Editor: Autologous transplantation of the adrenal medulla into the caudate nucleus has been used as a treatment for Parkinson's disease. The rationale for this approach is that the production of catecholamines by the chromaffin cells may restore the dopamine lost at the terminals of degenerated nigrostriatal neurons.1 This has been shown to be a promising therapy in selected patients.2 However, an earlier report of a study involving two older patients did not show promise.1 It is possible that the unknown factor or factors causing Parkinson's disease or the extended drug therapy for this syndrome have a debilitating effect.",

author = "Carmiohael, {Stephen W.} and Wilson, {Robert J.} and Brimijoin, {W. Stephen} and Melton, {L. Joseph} and Haruo Okazaki and Yaksh, {Tony L.} and Ahlskog, {J. Eric} and Stoddard, {Susan L.} and Tyce, {Gertrude M.}",

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AU - Carmiohael, Stephen W.

AU - Wilson, Robert J.

AU - Brimijoin, W. Stephen

AU - Melton, L. Joseph

AU - Okazaki, Haruo

AU - Yaksh, Tony L.

AU - Ahlskog, J. Eric

AU - Stoddard, Susan L.

AU - Tyce, Gertrude M.

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N2 - To the Editor: Autologous transplantation of the adrenal medulla into the caudate nucleus has been used as a treatment for Parkinson's disease. The rationale for this approach is that the production of catecholamines by the chromaffin cells may restore the dopamine lost at the terminals of degenerated nigrostriatal neurons.1 This has been shown to be a promising therapy in selected patients.2 However, an earlier report of a study involving two older patients did not show promise.1 It is possible that the unknown factor or factors causing Parkinson's disease or the extended drug therapy for this syndrome have a debilitating effect.

AB - To the Editor: Autologous transplantation of the adrenal medulla into the caudate nucleus has been used as a treatment for Parkinson's disease. The rationale for this approach is that the production of catecholamines by the chromaffin cells may restore the dopamine lost at the terminals of degenerated nigrostriatal neurons.1 This has been shown to be a promising therapy in selected patients.2 However, an earlier report of a study involving two older patients did not show promise.1 It is possible that the unknown factor or factors causing Parkinson's disease or the extended drug therapy for this syndrome have a debilitating effect.

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Decreased Catecholamines in the Adrenal Medulla of Patients with Parkinsonism

Abstract

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