Decreased Catecholamines in the Adrenal Medulla of Patients with Parkinsonism

Stephen W. Carmiohael, Robert J. Wilson, W. Stephen Brimijoin, L. Joseph Melton, Haruo Okazaki, Tony L. Yaksh, J. Eric Ahlskog, Susan L. Stoddard, Gertrude M. Tyce

Research output: Contribution to journalLetter

37 Scopus citations

Abstract

To the Editor: Autologous transplantation of the adrenal medulla into the caudate nucleus has been used as a treatment for Parkinson's disease. The rationale for this approach is that the production of catecholamines by the chromaffin cells may restore the dopamine lost at the terminals of degenerated nigrostriatal neurons.1 This has been shown to be a promising therapy in selected patients.2 However, an earlier report of a study involving two older patients did not show promise.1 It is possible that the unknown factor or factors causing Parkinson's disease or the extended drug therapy for this syndrome have a debilitating effect.

Original languageEnglish (US)
Pages (from-to)254
Number of pages1
JournalNew England Journal of Medicine
Volume318
Issue number4
DOIs
StatePublished - Jan 28 1988

ASJC Scopus subject areas

  • Medicine(all)

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    Carmiohael, S. W., Wilson, R. J., Brimijoin, W. S., Melton, L. J., Okazaki, H., Yaksh, T. L., Ahlskog, J. E., Stoddard, S. L., & Tyce, G. M. (1988). Decreased Catecholamines in the Adrenal Medulla of Patients with Parkinsonism. New England Journal of Medicine, 318(4), 254. https://doi.org/10.1056/NEJM198801283180415