Death-associated protein kinase 1 variation and Parkinson's disease

J. C. Dachsel, C. Wider, C. Vilariño-Güell, J. O. Aasly, A. Rajput, A. H. Rajput, T. Lynch, D. Craig, A. Krygowska-Wajs, B. Jasinska-Myga, G. Opala, M. Barcikowska, K. Czyzewski, R. M. Wu, M. G. Heckman, R. J. Uitti, Zbigniew K Wszolek, M. J. Farrer, Owen A Ross

Research output: Contribution to journalArticle

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Abstract

Background and purpose: Mutations of the LRRK2 gene are now recognized as major risk factors for Parkinson's disease. The Lrrk2 protein is a member of the ROCO family, which also includes Lrrk1 and Dapk1. Functional genetic variants of the DAPK1 gene (rs4877365 and rs4878104) have been previously associated with Alzheimer's disease. Methods: Herein, we assessed the role of DAPK1 variants (rs4877365 and rs4878104) in risk of Parkinson's disease with Sequenom iPLEX genotyping, employing one Taiwanese series (391 patients with Parkinson's disease, 344 controls) and five separate Caucasian series' (combined sample size 1962 Parkinson's disease patients, 1900 controls). Results: We observed no evidence of association for rs4877365 and rs4878104 and risk of Parkinson's disease in any of the individual series or in the combined Caucasian series under either an additive or recessive model. Conclusion: These specific DAPK1 intronic variants do not increase the risk of Parkinson's disease. However, further functional studies are required to elucidate the potential therapeutic implications with the dimerization of the Dapk1 and Lrrk2 proteins.

Original languageEnglish (US)
Pages (from-to)1090-1093
Number of pages4
JournalEuropean Journal of Neurology
Volume18
Issue number8
DOIs
StatePublished - Aug 2011

Fingerprint

Death-Associated Protein Kinases
Parkinson Disease
Dimerization
Sample Size
Genes
Alzheimer Disease
Proteins
Mutation

Keywords

  • DAPK1
  • Genetics
  • LRRK2
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Dachsel, J. C., Wider, C., Vilariño-Güell, C., Aasly, J. O., Rajput, A., Rajput, A. H., ... Ross, O. A. (2011). Death-associated protein kinase 1 variation and Parkinson's disease. European Journal of Neurology, 18(8), 1090-1093. https://doi.org/10.1111/j.1468-1331.2010.03255.x

Death-associated protein kinase 1 variation and Parkinson's disease. / Dachsel, J. C.; Wider, C.; Vilariño-Güell, C.; Aasly, J. O.; Rajput, A.; Rajput, A. H.; Lynch, T.; Craig, D.; Krygowska-Wajs, A.; Jasinska-Myga, B.; Opala, G.; Barcikowska, M.; Czyzewski, K.; Wu, R. M.; Heckman, M. G.; Uitti, R. J.; Wszolek, Zbigniew K; Farrer, M. J.; Ross, Owen A.

In: European Journal of Neurology, Vol. 18, No. 8, 08.2011, p. 1090-1093.

Research output: Contribution to journalArticle

Dachsel, JC, Wider, C, Vilariño-Güell, C, Aasly, JO, Rajput, A, Rajput, AH, Lynch, T, Craig, D, Krygowska-Wajs, A, Jasinska-Myga, B, Opala, G, Barcikowska, M, Czyzewski, K, Wu, RM, Heckman, MG, Uitti, RJ, Wszolek, ZK, Farrer, MJ & Ross, OA 2011, 'Death-associated protein kinase 1 variation and Parkinson's disease', European Journal of Neurology, vol. 18, no. 8, pp. 1090-1093. https://doi.org/10.1111/j.1468-1331.2010.03255.x
Dachsel JC, Wider C, Vilariño-Güell C, Aasly JO, Rajput A, Rajput AH et al. Death-associated protein kinase 1 variation and Parkinson's disease. European Journal of Neurology. 2011 Aug;18(8):1090-1093. https://doi.org/10.1111/j.1468-1331.2010.03255.x
Dachsel, J. C. ; Wider, C. ; Vilariño-Güell, C. ; Aasly, J. O. ; Rajput, A. ; Rajput, A. H. ; Lynch, T. ; Craig, D. ; Krygowska-Wajs, A. ; Jasinska-Myga, B. ; Opala, G. ; Barcikowska, M. ; Czyzewski, K. ; Wu, R. M. ; Heckman, M. G. ; Uitti, R. J. ; Wszolek, Zbigniew K ; Farrer, M. J. ; Ross, Owen A. / Death-associated protein kinase 1 variation and Parkinson's disease. In: European Journal of Neurology. 2011 ; Vol. 18, No. 8. pp. 1090-1093.
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