Death-associated protein kinase 1 variation and Parkinson's disease

J. C. Dachsel; C. Wider; C. Vilariño-Güell; J. O. Aasly; A. Rajput; A. H. Rajput; T. Lynch; D. Craig; A. Krygowska-Wajs; B. Jasinska-Myga; G. Opala; M. Barcikowska; K. Czyzewski; R. M. Wu; M. G. Heckman; R. J. Uitti; Z. K. Wszolek; M. J. Farrer; O. A. Ross

doi:10.1111/j.1468-1331.2010.03255.x

Death-associated protein kinase 1 variation and Parkinson's disease

J. C. Dachsel, C. Wider, C. Vilariño-Güell, J. O. Aasly, A. Rajput, A. H. Rajput, T. Lynch, D. Craig, A. Krygowska-Wajs, B. Jasinska-Myga, G. Opala, M. Barcikowska, K. Czyzewski, R. M. Wu, M. G. Heckman, R. J. Uitti, Z. K. Wszolek, M. J. Farrer, O. A. Ross

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background and purpose: Mutations of the LRRK2 gene are now recognized as major risk factors for Parkinson's disease. The Lrrk2 protein is a member of the ROCO family, which also includes Lrrk1 and Dapk1. Functional genetic variants of the DAPK1 gene (rs4877365 and rs4878104) have been previously associated with Alzheimer's disease. Methods: Herein, we assessed the role of DAPK1 variants (rs4877365 and rs4878104) in risk of Parkinson's disease with Sequenom iPLEX genotyping, employing one Taiwanese series (391 patients with Parkinson's disease, 344 controls) and five separate Caucasian series' (combined sample size 1962 Parkinson's disease patients, 1900 controls). Results: We observed no evidence of association for rs4877365 and rs4878104 and risk of Parkinson's disease in any of the individual series or in the combined Caucasian series under either an additive or recessive model. Conclusion: These specific DAPK1 intronic variants do not increase the risk of Parkinson's disease. However, further functional studies are required to elucidate the potential therapeutic implications with the dimerization of the Dapk1 and Lrrk2 proteins.

Original language	English (US)
Pages (from-to)	1090-1093
Number of pages	4
Journal	European Journal of Neurology
Volume	18
Issue number	8
DOIs	https://doi.org/10.1111/j.1468-1331.2010.03255.x
State	Published - Aug 2011

Keywords

DAPK1
Genetics
LRRK2
Parkinson's disease

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1111/j.1468-1331.2010.03255.x

Cite this

Dachsel, J. C., Wider, C., Vilariño-Güell, C., Aasly, J. O., Rajput, A., Rajput, A. H., Lynch, T., Craig, D., Krygowska-Wajs, A., Jasinska-Myga, B., Opala, G., Barcikowska, M., Czyzewski, K., Wu, R. M., Heckman, M. G., Uitti, R. J., Wszolek, Z. K., Farrer, M. J., & Ross, O. A. (2011). Death-associated protein kinase 1 variation and Parkinson's disease. European Journal of Neurology, 18(8), 1090-1093. https://doi.org/10.1111/j.1468-1331.2010.03255.x

Dachsel, JC, Wider, C, Vilariño-Güell, C, Aasly, JO, Rajput, A, Rajput, AH, Lynch, T, Craig, D, Krygowska-Wajs, A, Jasinska-Myga, B, Opala, G, Barcikowska, M, Czyzewski, K, Wu, RM, Heckman, MG, Uitti, RJ, Wszolek, ZK, Farrer, MJ & Ross, OA 2011, 'Death-associated protein kinase 1 variation and Parkinson's disease', European Journal of Neurology, vol. 18, no. 8, pp. 1090-1093. https://doi.org/10.1111/j.1468-1331.2010.03255.x

@article{2f92ed5c432449b3b1db25292e9b85eb,

title = "Death-associated protein kinase 1 variation and Parkinson's disease",

abstract = "Background and purpose: Mutations of the LRRK2 gene are now recognized as major risk factors for Parkinson's disease. The Lrrk2 protein is a member of the ROCO family, which also includes Lrrk1 and Dapk1. Functional genetic variants of the DAPK1 gene (rs4877365 and rs4878104) have been previously associated with Alzheimer's disease. Methods: Herein, we assessed the role of DAPK1 variants (rs4877365 and rs4878104) in risk of Parkinson's disease with Sequenom iPLEX genotyping, employing one Taiwanese series (391 patients with Parkinson's disease, 344 controls) and five separate Caucasian series' (combined sample size 1962 Parkinson's disease patients, 1900 controls). Results: We observed no evidence of association for rs4877365 and rs4878104 and risk of Parkinson's disease in any of the individual series or in the combined Caucasian series under either an additive or recessive model. Conclusion: These specific DAPK1 intronic variants do not increase the risk of Parkinson's disease. However, further functional studies are required to elucidate the potential therapeutic implications with the dimerization of the Dapk1 and Lrrk2 proteins.",

keywords = "DAPK1, Genetics, LRRK2, Parkinson's disease",

author = "Dachsel, {J. C.} and C. Wider and C. Vilari{\~n}o-G{\"u}ell and Aasly, {J. O.} and A. Rajput and Rajput, {A. H.} and T. Lynch and D. Craig and A. Krygowska-Wajs and B. Jasinska-Myga and G. Opala and M. Barcikowska and K. Czyzewski and Wu, {R. M.} and Heckman, {M. G.} and Uitti, {R. J.} and Wszolek, {Z. K.} and Farrer, {M. J.} and Ross, {O. A.}",

year = "2011",

month = aug,

doi = "10.1111/j.1468-1331.2010.03255.x",

language = "English (US)",

volume = "18",

pages = "1090--1093",

journal = "European Journal of Neurology",

issn = "1351-5101",

publisher = "Wiley-Blackwell",

number = "8",

}

TY - JOUR

T1 - Death-associated protein kinase 1 variation and Parkinson's disease

AU - Dachsel, J. C.

AU - Wider, C.

AU - Vilariño-Güell, C.

AU - Aasly, J. O.

AU - Rajput, A.

AU - Rajput, A. H.

AU - Lynch, T.

AU - Craig, D.

AU - Krygowska-Wajs, A.

AU - Jasinska-Myga, B.

AU - Opala, G.

AU - Barcikowska, M.

AU - Czyzewski, K.

AU - Wu, R. M.

AU - Heckman, M. G.

AU - Uitti, R. J.

AU - Wszolek, Z. K.

AU - Farrer, M. J.

AU - Ross, O. A.

PY - 2011/8

Y1 - 2011/8

N2 - Background and purpose: Mutations of the LRRK2 gene are now recognized as major risk factors for Parkinson's disease. The Lrrk2 protein is a member of the ROCO family, which also includes Lrrk1 and Dapk1. Functional genetic variants of the DAPK1 gene (rs4877365 and rs4878104) have been previously associated with Alzheimer's disease. Methods: Herein, we assessed the role of DAPK1 variants (rs4877365 and rs4878104) in risk of Parkinson's disease with Sequenom iPLEX genotyping, employing one Taiwanese series (391 patients with Parkinson's disease, 344 controls) and five separate Caucasian series' (combined sample size 1962 Parkinson's disease patients, 1900 controls). Results: We observed no evidence of association for rs4877365 and rs4878104 and risk of Parkinson's disease in any of the individual series or in the combined Caucasian series under either an additive or recessive model. Conclusion: These specific DAPK1 intronic variants do not increase the risk of Parkinson's disease. However, further functional studies are required to elucidate the potential therapeutic implications with the dimerization of the Dapk1 and Lrrk2 proteins.

AB - Background and purpose: Mutations of the LRRK2 gene are now recognized as major risk factors for Parkinson's disease. The Lrrk2 protein is a member of the ROCO family, which also includes Lrrk1 and Dapk1. Functional genetic variants of the DAPK1 gene (rs4877365 and rs4878104) have been previously associated with Alzheimer's disease. Methods: Herein, we assessed the role of DAPK1 variants (rs4877365 and rs4878104) in risk of Parkinson's disease with Sequenom iPLEX genotyping, employing one Taiwanese series (391 patients with Parkinson's disease, 344 controls) and five separate Caucasian series' (combined sample size 1962 Parkinson's disease patients, 1900 controls). Results: We observed no evidence of association for rs4877365 and rs4878104 and risk of Parkinson's disease in any of the individual series or in the combined Caucasian series under either an additive or recessive model. Conclusion: These specific DAPK1 intronic variants do not increase the risk of Parkinson's disease. However, further functional studies are required to elucidate the potential therapeutic implications with the dimerization of the Dapk1 and Lrrk2 proteins.

KW - DAPK1

KW - Genetics

KW - LRRK2

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=79960321717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960321717&partnerID=8YFLogxK

U2 - 10.1111/j.1468-1331.2010.03255.x

DO - 10.1111/j.1468-1331.2010.03255.x

M3 - Article

C2 - 21749573

AN - SCOPUS:79960321717

SN - 1351-5101

VL - 18

SP - 1090

EP - 1093

JO - European Journal of Neurology

JF - European Journal of Neurology

IS - 8

ER -

Death-associated protein kinase 1 variation and Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this