Dachsous encodes a member of the cadherin superfamily that controls imaginai disc morphogenesis in Drosophila

Hilary F. Clark, Doris Brentrup, Kay Schneitz, Allan Bieber, Corey Goodman, Markus Noll

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

Mutations in the dachsous gene of Drosophila lead to striking defects in the morphogenesis of the thorax, legs, and wings. The dachsous gene has been cloned and shown to encode a huge transmembrane protein that is a member of the cadherin superfamily, similar to the fat gene reported previously. Both the Dachsous and Fat proteins contain large tandem arrays of cadherin domains-27 and 34, respectively - as compared with 4 cadherin domains in classic vertebrate cadherins. In addition, Dachsous and Fat each has a cytoplasmic domain with sequence similarity to the cytoplasmic β-catenin-binding domain of classic vertebrate cadherins. The dachsous gene is expressed in the ectoderm of embryos, whereas its expression in larvae is restricted to imaginai discs and specific regions of the brain. The phenotypes of, and genetic interactions between dachsous and fat are consistent with a model in which cell proliferation and morphogenesis of imaginai structures depends on the coupled equilibria between homo- and heterophilic interactions of the Dachsous and Fat cadherin proteins.

Original languageEnglish (US)
Pages (from-to)1530-1542
Number of pages13
JournalGenes and Development
Volume9
Issue number12
StatePublished - Jun 15 1995
Externally publishedYes

Fingerprint

Cadherins
Morphogenesis
Drosophila
Fats
Genes
Vertebrates
Catenins
Ectoderm
Proteins
Larva
Leg
Thorax
Embryonic Structures
Cell Proliferation
Phenotype
Mutation
Brain

Keywords

  • Cadherin
  • Cell adhesion
  • Dachsous
  • Disc morphogenesis

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics

Cite this

Clark, H. F., Brentrup, D., Schneitz, K., Bieber, A., Goodman, C., & Noll, M. (1995). Dachsous encodes a member of the cadherin superfamily that controls imaginai disc morphogenesis in Drosophila. Genes and Development, 9(12), 1530-1542.

Dachsous encodes a member of the cadherin superfamily that controls imaginai disc morphogenesis in Drosophila. / Clark, Hilary F.; Brentrup, Doris; Schneitz, Kay; Bieber, Allan; Goodman, Corey; Noll, Markus.

In: Genes and Development, Vol. 9, No. 12, 15.06.1995, p. 1530-1542.

Research output: Contribution to journalArticle

Clark, HF, Brentrup, D, Schneitz, K, Bieber, A, Goodman, C & Noll, M 1995, 'Dachsous encodes a member of the cadherin superfamily that controls imaginai disc morphogenesis in Drosophila', Genes and Development, vol. 9, no. 12, pp. 1530-1542.
Clark HF, Brentrup D, Schneitz K, Bieber A, Goodman C, Noll M. Dachsous encodes a member of the cadherin superfamily that controls imaginai disc morphogenesis in Drosophila. Genes and Development. 1995 Jun 15;9(12):1530-1542.
Clark, Hilary F. ; Brentrup, Doris ; Schneitz, Kay ; Bieber, Allan ; Goodman, Corey ; Noll, Markus. / Dachsous encodes a member of the cadherin superfamily that controls imaginai disc morphogenesis in Drosophila. In: Genes and Development. 1995 ; Vol. 9, No. 12. pp. 1530-1542.
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