D-Penicillamine in Felty's syndrome

S. Lakhanpal, H. S. Luthra

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We report our experience with 8 patients with Felty's syndrome who were treated with D-penicillamine for a mean of one year. Six of the 8 patients experienced improvement in their neutropenia. Cutaneous ulcers healed in 4 of 6, while recurrent infections cleared in 3 of 5 patients. The drug was withdrawn in 6 patients - lack of response in one, thrombocytopenia in one, urticaria in one, rash in one, and granulocytopenia in 2. One of the latter 2 patients developed pancytopenia and died. Although D-penicillamine is effective in treatment of Felty's syndrome, its side effects can be serious and potentially lethal. Its use should be limited to patients who have failed other treatments.

Original languageEnglish (US)
Pages (from-to)703-706
Number of pages4
JournalJournal of Rheumatology
Volume12
Issue number4
StatePublished - 1985

Fingerprint

Felty Syndrome
Penicillamine
Skin Ulcer
Pancytopenia
Agranulocytosis
Urticaria
Exanthema
Neutropenia
Thrombocytopenia
Therapeutics
Infection
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Lakhanpal, S., & Luthra, H. S. (1985). D-Penicillamine in Felty's syndrome. Journal of Rheumatology, 12(4), 703-706.

D-Penicillamine in Felty's syndrome. / Lakhanpal, S.; Luthra, H. S.

In: Journal of Rheumatology, Vol. 12, No. 4, 1985, p. 703-706.

Research output: Contribution to journalArticle

Lakhanpal, S & Luthra, HS 1985, 'D-Penicillamine in Felty's syndrome', Journal of Rheumatology, vol. 12, no. 4, pp. 703-706.
Lakhanpal S, Luthra HS. D-Penicillamine in Felty's syndrome. Journal of Rheumatology. 1985;12(4):703-706.
Lakhanpal, S. ; Luthra, H. S. / D-Penicillamine in Felty's syndrome. In: Journal of Rheumatology. 1985 ; Vol. 12, No. 4. pp. 703-706.
@article{c5c6b26442104c71a40722b8af139ebc,
title = "D-Penicillamine in Felty's syndrome",
abstract = "We report our experience with 8 patients with Felty's syndrome who were treated with D-penicillamine for a mean of one year. Six of the 8 patients experienced improvement in their neutropenia. Cutaneous ulcers healed in 4 of 6, while recurrent infections cleared in 3 of 5 patients. The drug was withdrawn in 6 patients - lack of response in one, thrombocytopenia in one, urticaria in one, rash in one, and granulocytopenia in 2. One of the latter 2 patients developed pancytopenia and died. Although D-penicillamine is effective in treatment of Felty's syndrome, its side effects can be serious and potentially lethal. Its use should be limited to patients who have failed other treatments.",
author = "S. Lakhanpal and Luthra, {H. S.}",
year = "1985",
language = "English (US)",
volume = "12",
pages = "703--706",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "4",

}

TY - JOUR

T1 - D-Penicillamine in Felty's syndrome

AU - Lakhanpal, S.

AU - Luthra, H. S.

PY - 1985

Y1 - 1985

N2 - We report our experience with 8 patients with Felty's syndrome who were treated with D-penicillamine for a mean of one year. Six of the 8 patients experienced improvement in their neutropenia. Cutaneous ulcers healed in 4 of 6, while recurrent infections cleared in 3 of 5 patients. The drug was withdrawn in 6 patients - lack of response in one, thrombocytopenia in one, urticaria in one, rash in one, and granulocytopenia in 2. One of the latter 2 patients developed pancytopenia and died. Although D-penicillamine is effective in treatment of Felty's syndrome, its side effects can be serious and potentially lethal. Its use should be limited to patients who have failed other treatments.

AB - We report our experience with 8 patients with Felty's syndrome who were treated with D-penicillamine for a mean of one year. Six of the 8 patients experienced improvement in their neutropenia. Cutaneous ulcers healed in 4 of 6, while recurrent infections cleared in 3 of 5 patients. The drug was withdrawn in 6 patients - lack of response in one, thrombocytopenia in one, urticaria in one, rash in one, and granulocytopenia in 2. One of the latter 2 patients developed pancytopenia and died. Although D-penicillamine is effective in treatment of Felty's syndrome, its side effects can be serious and potentially lethal. Its use should be limited to patients who have failed other treatments.

UR - http://www.scopus.com/inward/record.url?scp=0021997268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021997268&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 703

EP - 706

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 4

ER -