Cytomegalovirus infection in orthotopic liver transplantation

L. H. Sayage, T. A. Gonwa, R. M. Goldstein, B. S. Husberg, G. B. Klintmalm

Research output: Contribution to journalArticle

Abstract

We retrospectively studied 175 orthotopic liver transplants in 151 patients. Of the 151 patients, 59 (39.1%) were diagnosed as having cytomegalovirus (CMV) infection. The rate of infection in patients treated for rejection was 48.8% as compared to 26.2% in patients without rejection (P<0.01). Antirejection therapy was associated with culture-positive cases in 33 out of 43 patients as compared to 9 out of 16 patients who had CMV antibody titer elevations. Patients were treated with gancyclovir if they had simultaneous positive cultures from multiple sites and were seriously ill. Eighteen of the 19 patients thus treated had side effects, one of which was serious (bone marrow hypoplasia). Cultures became negative in 15 out of 17 (88%) of the surviving patients. Patient survival was similar to our overall survival rate of 87%.

Original languageEnglish (US)
Pages (from-to)96-101
Number of pages6
JournalTransplant International
Volume2
Issue number2
DOIs
StatePublished - Aug 1 1989

Keywords

  • Cytomegalovirus infection, in liver transplantation
  • Gancyclovir, for cytomegalovirus infection, in liver transplantation
  • Liver transplantation, and cytomegalovirus infection

ASJC Scopus subject areas

  • Transplantation

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  • Cite this

    Sayage, L. H., Gonwa, T. A., Goldstein, R. M., Husberg, B. S., & Klintmalm, G. B. (1989). Cytomegalovirus infection in orthotopic liver transplantation. Transplant International, 2(2), 96-101. https://doi.org/10.1007/BF02459327