Cytokines and immune responses in murine atherosclerosis

Pascal J.H. Kusters, Esther Lutgens

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Atherosclerosis is an inflammatory disease of the vessel wall characterized by activation of the innate immune system, with macrophages as the main players, as well as the adaptive immune system, characterized by a Th1-dominant immune response. Cytokines play a major role in the initiation and regulation of inflammation. In recent years, many studies have investigated the role of these molecules in experimental models of atherosclerosis. While some cytokines such as TNF or IFNγ clearly had atherogenic effects, others such as IL-10 were found to be atheroprotective. However, studies investigating the different cytokines in experimental atherosclerosis revealed that the cytokine system is complex with both disease stagedependent and site-specific effects. In this review, we strive to provide an overview of the main cytokines involved in atherosclerosis and to shed light on their individual role during atherogenesis

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages17-40
Number of pages24
DOIs
StatePublished - 2015

Publication series

NameMethods in Molecular Biology
Volume1339
ISSN (Print)1064-3745

Keywords

  • Atherosclerosis
  • Cytokines
  • Experimental atherosclerosis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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