Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers

Marie A. Herrmann, Ian D Hay, Duane H. Barteit, Steven R. Ritland, Richard J. Dahl, Clive S. Grant, Robert Brian Jenkins

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Cytogenetic studies have shown frequent clonal abnormalities in papillary carcinoma (PTC) and follicular carcinoma (FTC). Loss of heterozygosity (LOH) may suggest the presence of tumor suppressor genes and has not been reported in these neoplasms. These studies were undertaken to determine if consistent chromosomal abnormalities are associated with thyroid cancer, to determine likely regions for molecular genetic investigations, and to determine if there is allelic loss in thyroid tumors. Cytogenetic analysis of 26 PTC and 5 FTC showed clonal abnormalities in 9 and included -Y, +5, or inv(10)(q11.2q21.2) in PTC, and -Y or near haploidy in FTC. Using DNA probes specific for chromosomes 1, 3, 10, 16, and 17, we carried out restriction fragment length polymorphism analysis on 6 FTC, 3 follicular adenomas (FA), and 12 PTC. LOH of all informative loci on chromosome 3p was observed in all 6 FTC, but not in FA or PTC. No LOH was observed for loci mapped to chromosome 10 in PTC. Our results suggest: cytogenetic abnormalities of chromosome 10q are associated with PTC; cytogenetic and molecular abnormalities of chromosome 3 are associated with FTC; and a tumor suppressor gene may be present on the short arm of chromosome 3 important for the development or progression of FTC.

Original languageEnglish (US)
Pages (from-to)1596-1604
Number of pages9
JournalJournal of Clinical Investigation
Volume88
Issue number5
StatePublished - 1991

Fingerprint

Factor IX
Cytogenetics
Molecular Biology
Loss of Heterozygosity
Chromosomes, Human, Pair 3
Chromosome Aberrations
Tumor Suppressor Genes
Adenoma
Chromosomes
Carcinoma, Papillary, Follicular
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 1
Cytogenetic Analysis
Haploidy
DNA Probes
Follicular Thyroid cancer
Papillary Thyroid cancer
Thyroid Neoplasms
Restriction Fragment Length Polymorphisms
Neoplasms

Keywords

  • Carcinoma
  • Chromosome analysis
  • Endocrine tumors
  • Neoplasia
  • Tumorigenesis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Herrmann, M. A., Hay, I. D., Barteit, D. H., Ritland, S. R., Dahl, R. J., Grant, C. S., & Jenkins, R. B. (1991). Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers. Journal of Clinical Investigation, 88(5), 1596-1604.

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers. / Herrmann, Marie A.; Hay, Ian D; Barteit, Duane H.; Ritland, Steven R.; Dahl, Richard J.; Grant, Clive S.; Jenkins, Robert Brian.

In: Journal of Clinical Investigation, Vol. 88, No. 5, 1991, p. 1596-1604.

Research output: Contribution to journalArticle

Herrmann, MA, Hay, ID, Barteit, DH, Ritland, SR, Dahl, RJ, Grant, CS & Jenkins, RB 1991, 'Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers', Journal of Clinical Investigation, vol. 88, no. 5, pp. 1596-1604.
Herrmann MA, Hay ID, Barteit DH, Ritland SR, Dahl RJ, Grant CS et al. Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers. Journal of Clinical Investigation. 1991;88(5):1596-1604.
Herrmann, Marie A. ; Hay, Ian D ; Barteit, Duane H. ; Ritland, Steven R. ; Dahl, Richard J. ; Grant, Clive S. ; Jenkins, Robert Brian. / Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers. In: Journal of Clinical Investigation. 1991 ; Vol. 88, No. 5. pp. 1596-1604.
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